Antimycoplasmal activities of (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-[4-(2-pyridyl)-1-piperazinyl]-7-oxo-7H-pyrido[1,2,3-de][1,4] benzoxazine-6-carboxylic acid (YH-6) in comparison with other antibiotics in vitro
文献类型：期刊论文
| 作者 | Ye, H; Wu, JM; Yang, YS ; Ji, RY; Chen, KX
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1999-11 |
| 卷号 | 20期号:11页码:1031-1034 |
| 关键词 | Mycoplasma Ureaplasma erythromycin leucomycins tetracycline josamycin tylosin microbial sensitivity tests microbial drug resistence |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To determine the susceptibilities of Mycoplasma and Ureaplasma to (S)-(-)-9-fluoro-2, 3-dihydro-3-methyl-10- [4-( 2-pyridyl)-1-piperazinyl]-7-oxo-7H-pyrido[1,2,3-de] [1,4] benzoxazine-6-carboxylic acid (YH-6) and to compare it with those referential quinolones, macrolides, and tetracyclines. METHODS: The minimum inhibitory concentration (MIC) were determined by microdilution method in vitro. RESULTS: The MIC of YH-6 for Ureaplasma urealyticum (Uu: 250 mu .L-1), Mycoplasma hominis (Mh: 500 mu g . L-1), M orale (Mo: 125 mu g . L-1) and M salivarium ( Ms: 125 mu g . L-1) were closely similar to those of macrolides (erythromycin and leucomycin) and were 2-8 folds greater than those of ofloxacin (Ofl). Un and Mh easily induced resistance to erythromycin and tetracycline. They did not easily form resistance to quinolone (YH-6, Ofl), josamycin and tylosin. Tetracycline-resistance (Tc-r) or erythromycin-resistance (EMC) strains of Uu (or Mh.) had cross-resistance to erythromycin or tetracycline. However, they had no cross-resistance to quinolone, josamycin and tylosin. CONCLUSION: YH-6 was a highly active quinolone against Mycoplasma, but could hardly induce resistance to Uu. EMr- or Tc-r- strains of Uu (or Mh) had no cross-resistance to YH-6. |
| WOS关键词 | TETRACYCLINE RESISTANCE ; UREAPLASMA-UREALYTICUM ; MYCOPLASMA-HOMINIS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000083583700014 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274680]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, JM |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, H,Wu, JM,Yang, YS,et al. Antimycoplasmal activities of (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-[4-(2-pyridyl)-1-piperazinyl]-7-oxo-7H-pyrido[1,2,3-de][1,4] benzoxazine-6-carboxylic acid (YH-6) in comparison with other antibiotics in vitro[J]. ACTA PHARMACOLOGICA SINICA,1999,20(11):1031-1034. |
| APA | Ye, H,Wu, JM,Yang, YS,Ji, RY,&Chen, KX.(1999).Antimycoplasmal activities of (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-[4-(2-pyridyl)-1-piperazinyl]-7-oxo-7H-pyrido[1,2,3-de][1,4] benzoxazine-6-carboxylic acid (YH-6) in comparison with other antibiotics in vitro.ACTA PHARMACOLOGICA SINICA,20(11),1031-1034. |
| MLA | Ye, H,et al."Antimycoplasmal activities of (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-[4-(2-pyridyl)-1-piperazinyl]-7-oxo-7H-pyrido[1,2,3-de][1,4] benzoxazine-6-carboxylic acid (YH-6) in comparison with other antibiotics in vitro".ACTA PHARMACOLOGICA SINICA 20.11(1999):1031-1034. |
入库方式： OAI收割
来源：上海药物研究所
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