Pharmacokinetics of intragastric ipriflavone solid dispersion in rats
文献类型：期刊论文
| 作者 | Li, YP ; Zhou, JJ; Zhang, XY
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1999-11 |
| 卷号 | 20期号:11页码:1035-1038 |
| 关键词 | pharmacokinetics ipriflavone isoflavones high pressure liquid chromatography biological availability |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To evaluate pharmacokinetic behavior of ipriflavone solid dispersion in rats. METHODS: The plasma concentrations of ipriflavone in rats were determined by HPLC with UV detector. RESULTS: Plasma concentration-time curves after ig ipriflavone solid dispersion 250 mg kg(-1) in rats were fitted with one-compartment model. Pharmacokinetic parameters were as follows: K-e = 0.21 h(-1), T1/2(Ke) = 5.19 h, K-a = 1.71 h(-1), T1/2(Ka) = 0.41 h, T-max = 0.67 h, C-max = 429 mu g.L-1 , AUC = 3916 mu g.h.L-1; The relative bioavailability of ipriflavone solid dispersion was 323 %. CONCLUSION: Ipriflavone in solid dispersion was absorbed more effectively than that in physical mixture in rats. |
| WOS关键词 | ABSORPTION |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000083583700015 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274681]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, YP |
| 作者单位 | 1.Shanghai Med Univ, Sch Pharm, Dept Pharmaceut, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, YP,Zhou, JJ,Zhang, XY. Pharmacokinetics of intragastric ipriflavone solid dispersion in rats[J]. ACTA PHARMACOLOGICA SINICA,1999,20(11):1035-1038. |
| APA | Li, YP,Zhou, JJ,&Zhang, XY.(1999).Pharmacokinetics of intragastric ipriflavone solid dispersion in rats.ACTA PHARMACOLOGICA SINICA,20(11),1035-1038. |
| MLA | Li, YP,et al."Pharmacokinetics of intragastric ipriflavone solid dispersion in rats".ACTA PHARMACOLOGICA SINICA 20.11(1999):1035-1038. |
入库方式： OAI收割
来源：上海药物研究所
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