Preparation and dissolution property of ipriflavone solid dispersion
文献类型：期刊论文
| 作者 | Li, YP ; Zhang, XY; Zhou, JJ; Pei, YY
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1999-10 |
| 卷号 | 20期号:10页码:957-960 |
| 关键词 | ipriflavones isoflavones pharmaceutical preparations povidone polyethylene glycols |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To prepare and identify ipriflavone (IP) solid dispersion, and determine its dissolution property. METHODS: The solvent method was used for preparation and differential scanning calorimetry (DSC), X-ray diffraction and infrared spectrophotometry for identification of IP solid dispersion. The dissolution of the dispersion was determined with paddle method. RESULTS: The dissolution of IP solid dispersion consisting of IP and povidone-k30 (PVP) (1 :8) in artificial gastric juice is 6.15 times as high as that of IP alone. The DSC curves, X-ray diffraction patterns and infrared spectrophotometries of IP have been changed obviously by the dispersion. CONCLUSION: The dissolution of IP is increased by solid dispersion method. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000083036100019 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274686]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, YP |
| 作者单位 | 1.Shanghai Med Univ, Sch Pharm, Dept Pharmaceut, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, YP,Zhang, XY,Zhou, JJ,et al. Preparation and dissolution property of ipriflavone solid dispersion[J]. ACTA PHARMACOLOGICA SINICA,1999,20(10):957-960. |
| APA | Li, YP,Zhang, XY,Zhou, JJ,&Pei, YY.(1999).Preparation and dissolution property of ipriflavone solid dispersion.ACTA PHARMACOLOGICA SINICA,20(10),957-960. |
| MLA | Li, YP,et al."Preparation and dissolution property of ipriflavone solid dispersion".ACTA PHARMACOLOGICA SINICA 20.10(1999):957-960. |
入库方式： OAI收割
来源：上海药物研究所
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