Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice
文献类型：期刊论文
| 作者 | Wu, WR; Zheng, JW; Li, N; Bai, HQ; Zhang, KR; Li, Y
|
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 1999-02-05 |
| 卷号 | 366期号:2-3页码:261-269 |
| 关键词 | dihydroetorphine immunosuppression dependence |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/S0014-2999(98)00915-7 |
| 文献子类 | Article |
| 英文摘要 | The immunomodulatory effects of dihydroetorphine were systematically investigated in subchronically treated mice. In a dose-dependent fashion, dihydroetorphine (total doses at 444.5, 889 and 1778 mu g/kg) lowered the increase of body weight, decreased the weight of the spleen and thymus, weakened the delayed-type hypersensitivity, reduced the generation of antibody-forming cells, inhibited splenic lymphocyte proliferation induced by concanavalin A and lipopolysaccharide, suppressed the production of interleukin-2 in the supernatant of splenocytes induced by concanavalin A, and depleted the ratio of CD4(+) and CD8(+) subpopulations. Moreover, the physical dependence on dihydroetorphine was also evaluated to confirm that the immunosuppression was concomitant with the addiction to thr drug. These results demonstrate that subchronic treatment with dihydroetorphine dose dependently suppresses both humoral and cell-mediated immune function, and that the immunosuppressive effects of dihydroetorphine are much more potent than those of morphine. (C) 1999 Elsevier Science B.V. All rights reserved. |
| WOS关键词 | MORPHINE-INDUCED ALTERATIONS ; MECHANISM ; SUPPRESSION ; SPECIFICITY ; RESPONSES ; RECEPTORS ; OPIATE |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000078564000017 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274752]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, WR |
| 作者单位 | 1.Xian Med Univ, Dept Pharmacol, Xian 710061, Peoples R China 2.Beijing Med Univ, Dept Immunol, Beijing 100083, Peoples R China 3.Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, WR,Zheng, JW,Li, N,et al. Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,1999,366(2-3):261-269. |
| APA | Wu, WR,Zheng, JW,Li, N,Bai, HQ,Zhang, KR,&Li, Y.(1999).Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice.EUROPEAN JOURNAL OF PHARMACOLOGY,366(2-3),261-269. |
| MLA | Wu, WR,et al."Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice".EUROPEAN JOURNAL OF PHARMACOLOGY 366.2-3(1999):261-269. |
入库方式： OAI收割
来源：上海药物研究所
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