Decomposition mechanism of an artemisinin-type compound via hemin-electrocatalysis
文献类型：期刊论文
| 作者 | Chen, HY; Chen, Y ; Zhu, SM; Bian, NS; Shan, F; Li, Y
|
| 刊名 | TALANTA
 |
| 出版日期 | 1999-01 |
| 卷号 | 48期号:1页码:143-150 |
| 关键词 | artemisinin derivative hemin decomposition mechanism HPLC UV-spectroelectrochemistry |
| ISSN号 | 0039-9140 |
| DOI | 10.1016/S0039-9140(98)00230-6 |
| 文献子类 | Article |
| 英文摘要 | The interaction between a typical derivative of artemisinin and hemin was investigated by electrochemical and spectroelectrochemical methods. This derivative can be reduced via hemin-catalysis at the glassy carbon electrode, the cathodic overpotential is decreased by ca. 650 mV. A HPLC method for separating the products of the catalytic reaction was established. They were identified either in H2O-CH3CN solution or in tetrahydrofuran, respectively. The structures of these products show that the hemin-catalyzed decomposition of an artemisinin-type compound on the glassy carbon or reticulated vitreous carbon electrode can be achieved by both electrochemical reduction and rearrangement. The conclusion that the reaction of artemisinin with hemin is a critical step in the antimalarial mechanism of artemisinin can be drawn. (C) 1999 Elsevier Science B.V. All rights reserved. |
| WOS关键词 | ANTIMALARIAL ENDOPEROXIDES ; QINGHAOSU ; METABOLISM |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000077958700017 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274781]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, HY |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Nanjing Univ, State Key Lab Coordinat Chem, Dept Chem, Nanjing 210093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, HY,Chen, Y,Zhu, SM,et al. Decomposition mechanism of an artemisinin-type compound via hemin-electrocatalysis[J]. TALANTA,1999,48(1):143-150. |
| APA | Chen, HY,Chen, Y,Zhu, SM,Bian, NS,Shan, F,&Li, Y.(1999).Decomposition mechanism of an artemisinin-type compound via hemin-electrocatalysis.TALANTA,48(1),143-150. |
| MLA | Chen, HY,et al."Decomposition mechanism of an artemisinin-type compound via hemin-electrocatalysis".TALANTA 48.1(1999):143-150. |
入库方式： OAI收割
来源：上海药物研究所
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