Involvement of mu-opioid receptors and alpha-adrenoceptors in the immunomodulatory effects of dihydroetorphine
文献类型：期刊论文
| 作者 | Wu, WR; Zheng, JW; Li, FY; Li, Y ; Zhang, KR; Bai, HQ
|
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 1998-07-17 |
| 卷号 | 353期号:1页码:79-85 |
| 关键词 | dihydroetorphine lymphocyte proliferation lymphokine production naloxone phentolamine propranolol |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/S0014-2999(98)00369-0 |
| 文献子类 | Article |
| 英文摘要 | The present study investigated the effects of acutely administered dihydroetorphine on mitogen-stimulated lymphocyte proliferation and lymphokine production in mice. These immune functions were significantly suppressed by dihydroetorphine at 24 mu g/kg and 128 mu g/kg in a dose-dependent fashion. This study further examined the involvement of mu-opioid receptors and alpha-adrenoceptors in the immunomodulatory effects of dihydroetorphine. The mu-opioid receptor antagonist, naloxone (4 mg/kg), and alpha-adrenoceptor antagonist, phentolamine (10 mg/kg), but not the beta-adrenoceptor antagonist, propranolol (10 mg/kg), effectively blocked dihydroetorphine-induced suppression of splenic lymphocyte proliferation and lymphokine production. These results demonstrate that dihydroetorphine has significant immunosuppressive effects in mice and the mechanisms of these effects may lie in its interactions with opioid receptors and adrenergic pathways. (C) 1998 Elsevier Science B.V. All rights reserved. |
| WOS关键词 | INDUCED IMMUNOSUPPRESSION ; OPIATE RECEPTORS ; MORPHINE ; SUPPRESSION ; MECHANISM ; SITES |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000075091800011 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274816]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, WR |
| 作者单位 | 1.Beijing Med Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China 2.Beijing Med Univ, Dept Immunol, Beijing 100083, Peoples R China 3.Xian Med Univ, Dept Pharmacol, Xian 710061, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, WR,Zheng, JW,Li, FY,et al. Involvement of mu-opioid receptors and alpha-adrenoceptors in the immunomodulatory effects of dihydroetorphine[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,1998,353(1):79-85. |
| APA | Wu, WR,Zheng, JW,Li, FY,Li, Y,Zhang, KR,&Bai, HQ.(1998).Involvement of mu-opioid receptors and alpha-adrenoceptors in the immunomodulatory effects of dihydroetorphine.EUROPEAN JOURNAL OF PHARMACOLOGY,353(1),79-85. |
| MLA | Wu, WR,et al."Involvement of mu-opioid receptors and alpha-adrenoceptors in the immunomodulatory effects of dihydroetorphine".EUROPEAN JOURNAL OF PHARMACOLOGY 353.1(1998):79-85. |
入库方式： OAI收割
来源：上海药物研究所
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