Dual effects of pentobarbital on rat sacral dorsal commissural neurons in vitro
文献类型：期刊论文
| 作者 | Pang, ZP; Xu, TL; Hu, GY; Li, JS |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1998-07 |
| 卷号 | 19期号:4页码:327-331 |
| 关键词 | pentobarbital GABA patch-clamp techniques neurons spinal cord |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effects of pentobarbital (PB) on acutely dissociated rat sacral dorsal commissural neurons (SDCN). METHODS: Nystatin-perforated patch clamp recording was used. RESULTS: (1) At a holding potential of - 40 mV, PB induced inward Cl- current (I-PB) in a concentration-dependent manner with a EC50 (95 % confidence limits) of 416 (385 - 477) mu mol.L-1 and a Hill coefficient of 1.08. (2) Picrotoxin reversibly blocked I-PB (3) The reversal potential of I-PB was close to the Cl- equilibrium potential. (4) PB enhanced GABA-induced Cl- influx (I-GABA) In the presence of PB 30 mu mol.L-1, the EC50 (95 % confidence limits) of I-GABA decreased from 6.9 (5.4-8.4) mu mol.L-1 to 3.5 (2.9 - 4.1) mu mol.L-1 CONCLUSION: PB had dual effects on SDCN, facilitated GABAA receptor-mediated currents, and at higher concentrations induced Cl- influx itself. |
| WOS关键词 | FROG SENSORY NEURONS ; SPINAL-CORD ; KINETIC-PROPERTIES ; CHLORIDE CURRENT ; RECEPTOR ; PROTEIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000074666500007 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274821]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xu, TL |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Fourth Mil Med Univ, KK Leung Brain Res Ctr, Dept Anat, Xian 710032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pang, ZP,Xu, TL,Hu, GY,et al. Dual effects of pentobarbital on rat sacral dorsal commissural neurons in vitro[J]. ACTA PHARMACOLOGICA SINICA,1998,19(4):327-331. |
| APA | Pang, ZP,Xu, TL,Hu, GY,&Li, JS.(1998).Dual effects of pentobarbital on rat sacral dorsal commissural neurons in vitro.ACTA PHARMACOLOGICA SINICA,19(4),327-331. |
| MLA | Pang, ZP,et al."Dual effects of pentobarbital on rat sacral dorsal commissural neurons in vitro".ACTA PHARMACOLOGICA SINICA 19.4(1998):327-331. |
入库方式： OAI收割
来源：上海药物研究所
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