Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage
文献类型：期刊论文
| 作者 | Chen, JX; Chen, WZ; Huang, HL; Chen, LX; Xie, ZZ; Zhu, BY |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1998-07 |
| 卷号 | 19期号:4页码:359-363 |
| 关键词 | Ginkgo biloba flavones ginkgolides lysophosphatidylcholines vascular endothelium epoprostenol malondialdehyde thoracic aorta vitamin E |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the protective effects of Ginkgo biloba extract (GbE) against endothelial cell damage induced by lysophosphatidylcholine (LPC). METHODS: The vasorelaxation response to acetylcholine (ACh) were investigated in the isolated rabbit thoracic aorta. Lipid peroxidation products were determined by measuring thiobarbituric acid reactive substance. RESULTS: GbE attenuated the inhibition of vasorelaxation response to ACh and prevented the LPC-induced increase of malondialdehyde (MDA) content both in thoracic aortae. GbE prevented the leakage of LDH and the increase of MDA content in cultured endothelial cells in a concentration-dependent manner. GbE also markedly increased epoprostenol level in cultured endothelial cells treated with LPC. CONCLUSION: GbE protected endothelial cells against LPC-induced damage due to reduction in lipid peroxidation and facilitation of synthesis and/or release of epoprostenol. |
| WOS关键词 | LOW-DENSITY LIPOPROTEINS ; DEPENDENT RELAXATION ; MYOCARDIAL-ISCHEMIA ; REPERFUSION INJURY ; RABBIT AORTA ; EGB-761 ; ACID |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000074666500015 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274822]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, WZ |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Hengyang Med Coll, Dept Pharmacol, Hengyang 421001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, JX,Chen, WZ,Huang, HL,et al. Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage[J]. ACTA PHARMACOLOGICA SINICA,1998,19(4):359-363. |
| APA | Chen, JX,Chen, WZ,Huang, HL,Chen, LX,Xie, ZZ,&Zhu, BY.(1998).Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage.ACTA PHARMACOLOGICA SINICA,19(4),359-363. |
| MLA | Chen, JX,et al."Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage".ACTA PHARMACOLOGICA SINICA 19.4(1998):359-363. |
入库方式： OAI收割
来源：上海药物研究所
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