Immunostimulatory action of L-4-oxalysine counteracts immunosuppression induced by alpha-fetoprotein
文献类型：期刊论文
| 作者 | Wang, XW; Xu, B
|
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 1998-06-12 |
| 卷号 | 351期号:1页码:105-111 |
| 关键词 | L-4-oxalysine alpha-fetoprotein mitogen reactivity lymphocyte reaction, one-way mixed interleukin-6 liver cancer |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/S0014-2999(98)00277-5 |
| 文献子类 | Article |
| 英文摘要 | We have previously reported that L-4-oxalysine, a natural product in China, exhibits marked antitumor and immunoregulatory activities. The present study was set up to investigate the effect of L-4-oxalysine on the immunological activity of alpha-fetoprotein. It was observed in in vitro experiments that concanavalin A reactivity, one-way mixed lymphocyte reaction and interleukin-6 activity of spleen cells from hepatoma-22-bearing mice were significantly inhibited by various concentrations of alpha-fetoprotein. However, L-4-oxalysine functionally antagonized the alpha-fetoprotein-induced suppression of the mitogen- and one-way mixed lymphocyte culture-induced proliferation of spleen lymphocytes and interleukin-6 production by these cells in mice bearing the hepatoma-22 tumor. The results indicate that L-4-oxalysine has immunostimulatory activity and this effect of the agent counteracts the immunosuppression induced by alpha-fetoprotein, although L-4-oxalysine does not directly antagonize alpha-fetoprotein. (C) 1998 Elsevier Science B.V. All rights reserved. |
| WOS关键词 | RAPID COLORIMETRIC ASSAY ; IMMUNE-RESPONSE ; CELLS INVITRO ; T-CELLS ; INTERLEUKIN-6 ; SUPPRESSION ; SURVIVAL ; GROWTH |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000074485300014 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274830]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, XW |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Cell Biol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, XW,Xu, B. Immunostimulatory action of L-4-oxalysine counteracts immunosuppression induced by alpha-fetoprotein[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,1998,351(1):105-111. |
| APA | Wang, XW,&Xu, B.(1998).Immunostimulatory action of L-4-oxalysine counteracts immunosuppression induced by alpha-fetoprotein.EUROPEAN JOURNAL OF PHARMACOLOGY,351(1),105-111. |
| MLA | Wang, XW,et al."Immunostimulatory action of L-4-oxalysine counteracts immunosuppression induced by alpha-fetoprotein".EUROPEAN JOURNAL OF PHARMACOLOGY 351.1(1998):105-111. |
入库方式： OAI收割
来源：上海药物研究所
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