Methionine-enkephalin stimulates interleukin-6 mRNA expression: Human plasma levels in coronary artery bypass grafting
文献类型：期刊论文
| 作者 | Zhong, F; Li, XY; Yang, SL; Stefano, GB; Fimiani, C; Bilfinger, TV |
| 刊名 | INTERNATIONAL JOURNAL OF CARDIOLOGY
 |
| 出版日期 | 1998-04-30 |
| 卷号 | 64页码:S53-S59 |
| 关键词 | methionine-enkephalin interleukin-6 gene expression messenger RNA human plasma |
| ISSN号 | 0167-5273 |
| DOI | 10.1016/S0167-5273(98)00036-9 |
| 文献子类 | Article |
| 英文摘要 | Opioid peptides have the ability to regulate immunocompetent cells. The present study extends this phenomenon to include an interaction with interleukin (IL)-6. We demonstrate that methionine-enkephalin (met-enkephalin) stimulates IL-6 mRNA expression in mice as determined by RNA isolation and hybridization with IL-6 cDNA, Ln mice, met-enkephalin [0.1 and 1 mg/kg intraperitoneal exposure for 6 days] also enhanced serum IL-6 levels. The in vivo data demonstrate that met-enkephalin upregulates IL-6 levels via an increase in transcriptional activity. Further, pre- and postoperative IL-6 and met-enkephalin levels were determined in the plasma of seven patients. First an increase in met-enkephalin plasma levels occurred (8.9 +/- 2.9 to 135 +/- 18 pg/ml; P<0.005), and then an increase in plasma IL-6 levels (2.1 +/- 1.5 to 237 +/- 50 pg/ml; P<0.001), suggesting that, as in mice, met-enkephalin induces IL-6 production. Taken together, the data strongly suggest that opioid peptides may be important as one of the chemical signaling molecules initiating the diffuse inflammatory response associated with coronary artery bypass grafting. (C) 1998 Elsevier Science Ireland Ltd. |
| WOS关键词 | CARDIOPULMONARY BYPASS ; PROINFLAMMATORY CYTOKINES ; TRANSCRIPTION FACTOR ; INJURY ; CELLS ; INVERTEBRATE ; REPERFUSION ; ACTIVATION ; MYOCARDIUM ; INDUCTION |
| 资助项目 | NCI NIH HHS[COR 17138] ; NIDA NIH HHS[NIDA 09010] ; PHS HHS[INT 00045] |
| WOS研究方向 | Cardiovascular System & Cardiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000074371900008 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274844]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, XY |
| 作者单位 | 1.SUNY Coll Old Westbury, Neurosci Res Inst, Old Westbury, NY 11568 USA 2.SUNY Stony Brook, Univ Hosp & Med Ctr, Cardiac Res Program, Stony Brook, NY 11794 USA 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 20031, Peoples R China 4.Chinese Acad Sci, Shanghai Res Ctr Biotechnol, Shanghai 200233, Peoples R China 5.Univ Rome La Sapienza, Dept Expt Med, Lab Cellular & Nat Immun, I-00185 Rome, Italy |
| 推荐引用方式 GB/T 7714 | Zhong, F,Li, XY,Yang, SL,et al. Methionine-enkephalin stimulates interleukin-6 mRNA expression: Human plasma levels in coronary artery bypass grafting[J]. INTERNATIONAL JOURNAL OF CARDIOLOGY,1998,64:S53-S59. |
| APA | Zhong, F,Li, XY,Yang, SL,Stefano, GB,Fimiani, C,&Bilfinger, TV.(1998).Methionine-enkephalin stimulates interleukin-6 mRNA expression: Human plasma levels in coronary artery bypass grafting.INTERNATIONAL JOURNAL OF CARDIOLOGY,64,S53-S59. |
| MLA | Zhong, F,et al."Methionine-enkephalin stimulates interleukin-6 mRNA expression: Human plasma levels in coronary artery bypass grafting".INTERNATIONAL JOURNAL OF CARDIOLOGY 64(1998):S53-S59. |
入库方式： OAI收割
来源：上海药物研究所
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