Enhancement of (-)-stepholidine on protein phosphorylation of a dopamine- and cAMP-regulated phosphoprotein in denervated striatum of oxidopamine-lesioned rats.
文献类型：期刊论文
| 作者 | Guo, X; Liu, J ; Zou, LL; Jin, J; Wang, BC; Jin, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1998-03 |
| 卷号 | 19期号:2页码:100-103 |
| 关键词 | stepholidine phosphoproteins phosphorylation dopamine D-1 receptors oxidopamine corpus striatum SK & F-38393 Sch-23390 |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study effects of (-)-stepholidine (SPD) on the phosphorylation of a dopamine- and cAMP-regulated phosphoprotein (DARPP-32) in the striatum of oxidopamine-lesioned rats. METHODS: The The mount of dephospho-DARPP-32 was measured by a back-phosphorylation assay. RESULTS: In the striatum of control rats, SPD per se had no effect on the phosphorylation of DARPP-32, but it antagonized the decrease by 28% of dephospho-DARPP-32 induced by the D-1 agonist SK&F-38393. In the denervated striatum of phosphorylation in the denervated striatum oxidopamine-lesioned rats, but it acts as a antagonist in normal striatum.oxidopamine-lesioned rats, SPD decreased the amount of dephospho-DARPP-32 by 44%. The effect of SPD was completely counteracted by the concomitant administration of the D-1 antagonist Sch-23390. CONCLUSION: SPD exhibits D-1 agonistic action of DARPP-32 phosphorylation in the denervated striatum oxidopamine-lesioned rats, but it acts as a antagonist in normal striatum. |
| WOS关键词 | DARPP-32 ; BRAIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000072465400002 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274851]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Jin, GZ |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.State Key Lab Nucl Med, Wuxi 214063, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, X,Liu, J,Zou, LL,et al. Enhancement of (-)-stepholidine on protein phosphorylation of a dopamine- and cAMP-regulated phosphoprotein in denervated striatum of oxidopamine-lesioned rats.[J]. ACTA PHARMACOLOGICA SINICA,1998,19(2):100-103. |
| APA | Guo, X,Liu, J,Zou, LL,Jin, J,Wang, BC,&Jin, GZ.(1998).Enhancement of (-)-stepholidine on protein phosphorylation of a dopamine- and cAMP-regulated phosphoprotein in denervated striatum of oxidopamine-lesioned rats..ACTA PHARMACOLOGICA SINICA,19(2),100-103. |
| MLA | Guo, X,et al."Enhancement of (-)-stepholidine on protein phosphorylation of a dopamine- and cAMP-regulated phosphoprotein in denervated striatum of oxidopamine-lesioned rats.".ACTA PHARMACOLOGICA SINICA 19.2(1998):100-103. |
入库方式： OAI收割
来源：上海药物研究所
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