Effect of catecholamic acid on detoxication and distribution of NiCl2 in mice and rats
文献类型：期刊论文
| 作者 | Yan, XM; Tao, ZQ; Liang, YY; Chen, ZJ; Zhang, JS; Xu, XH |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1998-01 |
| 卷号 | 19期号:1页码:80-84 |
| 关键词 | chelating agents catecholamic acid nickel lethal dose 50 autoradiography tissue distribution |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effect of catecholamic acid (CBMIDA) on detoxication of NiCl2. METHODS: Mice and rats were injected sc or im CBMIDA immediately after ip NiCl2. Each mouse was injected ip CBMIDA after iv (NiCl2)-Ni-63 185 kBq, and radioactivities of various tissues were measured with liquid scintillation counter at 24 h. The localization of Ni-63 was shown by the whole-body autoradiography. RESULTS: CBMIDA sc 0.5-1.5 g.kg(-1) markedly reduced the mortality from acute poisoning of ip NiCl2 500 mg.kg(-1). After ip NiCl2 in mice, the LD50 was 82.7 mg.kg(-1). Mice were injected sc CBMIDA 1.5 or 2.5 g.kg(-1) after Ni poisoning, the LD50 of NiCl2 were raised to 789 or 820 mg.kg(-1), respectively. The LD50 of NiCl2 was 39 mg.kg(-1) in rat. If CBMIDA was injected im 0.5 g.kg(-1) after ip NiCl2, the LD50 was 332 mg.kg(-1). CBMIDA 1.5 g.kg(-1) im after iv (NiCl2)-Ni-63, decreased the contents of Ni-63 in blood and lung of mice vs control mice at 24 h. The contents of Ni-63 in brain, heart, spleen, and kidney were similar to those of the control mice. The content of Ni-63 in bone was more than the control. The excretions of Ni-63 through urine and feces were not increased by CBMIDA at 24 h. The whole-body autoradiograpy showed that the radioactivity was highly localized in the kidney, lung, and Harder's gland. There was a moderate level of Ni-63 in the liver, bone, skin, and blood. A pronounced accumulation occurred in the bone. Them was a marked reduction of Ni-63 in the lung, skin, liver, and blood after ip CBMIDA. CONCLUSION: The CBMIDA markedly raised the survival rate of nickel-poisoned mice add rats, and decreased Ni-63 levels in lung and blood. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000071424500021 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274869]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yan, XM |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, XM,Tao, ZQ,Liang, YY,et al. Effect of catecholamic acid on detoxication and distribution of NiCl2 in mice and rats[J]. ACTA PHARMACOLOGICA SINICA,1998,19(1):80-84. |
| APA | Yan, XM,Tao, ZQ,Liang, YY,Chen, ZJ,Zhang, JS,&Xu, XH.(1998).Effect of catecholamic acid on detoxication and distribution of NiCl2 in mice and rats.ACTA PHARMACOLOGICA SINICA,19(1),80-84. |
| MLA | Yan, XM,et al."Effect of catecholamic acid on detoxication and distribution of NiCl2 in mice and rats".ACTA PHARMACOLOGICA SINICA 19.1(1998):80-84. |
入库方式： OAI收割
来源：上海药物研究所
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