Artesunate interaction with hemin
文献类型：期刊论文
| 作者 | Chen, Y ; Zhu, SM; Chen, HY; Li, Y
|
| 刊名 | BIOELECTROCHEMISTRY AND BIOENERGETICS
 |
| 出版日期 | 1998-01 |
| 卷号 | 44期号:2页码:295-300 |
| 关键词 | artesunate hemin catalyzed reduction cyclic voltammetry UV-spectroelectrochemistry |
| ISSN号 | 0302-4598 |
| DOI | 10.1016/S0302-4598(97)00076-7 |
| 文献子类 | Article |
| 英文摘要 | Artesunate is an important new antimalarial drug. The interaction of artesunate with hemin was investigated by electrochemical methods and UV spectroelectrochemistry (UV-SEC). Artesunate underwent an entirely irreversible reduction at ca. -1.27 V (vs. Ag/AgCl) on the glassy carbon electrode. Hemin can catalyze the decomposition of artesunate. In the presence of concentration of hemin as low as 2x10(-8) M, the cathodic overpotential of artesunate was reduced ca. 680 mV (E-pc = -0.59 V vs. Ag/AgCl). UV-SEC experiments further confirm this process. UV spectra show that the decomposed products of artesunate have absorption behavior similar to artesunate. These results indicated that artesunate might undergo the identical antimalarial mechanism as its parent compound Qinghaosu, and hemin plays a catalyst role in the process of action of Qinghaosu-type antimalarial drugs. (C) 1998 Elsevier Science S.A. |
| WOS关键词 | ARTEMISININ QINGHAOSU ; ANTIMALARIAL ; FALCIPARUM ; MALARIA |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000072830300020 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274870]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, HY |
| 作者单位 | 1.Acad Sinica, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Nanjing Univ, State Key Lab Coordinat Chem, Dept Chem, Nanjing 210093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Y,Zhu, SM,Chen, HY,et al. Artesunate interaction with hemin[J]. BIOELECTROCHEMISTRY AND BIOENERGETICS,1998,44(2):295-300. |
| APA | Chen, Y,Zhu, SM,Chen, HY,&Li, Y.(1998).Artesunate interaction with hemin.BIOELECTROCHEMISTRY AND BIOENERGETICS,44(2),295-300. |
| MLA | Chen, Y,et al."Artesunate interaction with hemin".BIOELECTROCHEMISTRY AND BIOENERGETICS 44.2(1998):295-300. |
入库方式： OAI收割
来源：上海药物研究所
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