Actions of salvianolic acid A on CCl4-poisoned liver injury and fibrosis in rats
文献类型：期刊论文
| 作者 | Hu, YY; Liu, P; Liu, C; Xu, LM; Liu, CH; Zhu, DY; Huang, MF |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1997-09 |
| 卷号 | 18期号:5页码:478-480 |
| 关键词 | salvianolic acid A carbon tetrachloride poisoning liver collagen Salvia miltiorrhiza alanine aminotransferase aspartate aminotransferase serum albumin liver cirrhosis malondialdehyde |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the actions of salvianolic acid A (SAA) on liver injury and liver fibrosis. METHODS: The liver fibrotic rat was made by ip injection of CCl4. The model rats were divided into 3 groups treated with SA-A, colchicine (Col), and Salvia miltiorrhiza Bunge (SMB), respectively. Six wk later the rat liver pathology was examined, type I and III collagen in the liver were examined by immunohistochemistical method. Also hydroxyproline (Hyd) and malondialdehyde (MDA) in the liver, alanine aminotransferase (AlaAT), aspartate aminotransferase (AspAT), and albumin (Alb) levels in the serum were measured. RESULTS: SA-A inhibited serum AlaAT and AspAT activities, decreased MDA and Hyd contents, alleviated liver fibrogenesis, protected deposition of type I and III collagen in liver matrix. The actions of SA-A on liver fibrosis were similar to those of Col and SMB, action of SA-A decreasing MDA was better than that of Col. CONCLUSION: SA-A has marked effects against liver injury and fibrosis, associated with its anti-lipid peroxidation actions. |
| WOS关键词 | LIPID-PEROXIDATION ; COLLAGEN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:162139 |
| WOS记录号 | WOS:A1997XV76300028 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274887]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hu, YY |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Hu, YY,Liu, P,Liu, C,et al. Actions of salvianolic acid A on CCl4-poisoned liver injury and fibrosis in rats[J]. ACTA PHARMACOLOGICA SINICA,1997,18(5):478-480. |
| APA | Hu, YY.,Liu, P.,Liu, C.,Xu, LM.,Liu, CH.,...&Huang, MF.(1997).Actions of salvianolic acid A on CCl4-poisoned liver injury and fibrosis in rats.ACTA PHARMACOLOGICA SINICA,18(5),478-480. |
| MLA | Hu, YY,et al."Actions of salvianolic acid A on CCl4-poisoned liver injury and fibrosis in rats".ACTA PHARMACOLOGICA SINICA 18.5(1997):478-480. |
入库方式： OAI收割
来源：上海药物研究所
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