Piperbetol, methylpiperbetol, piperol A and piperol B: A new series of highly specific PAF receptor antagonists from Piper betle
文献类型：期刊论文
| 作者 | Zeng, HW; Jiang, YY ; Cai, DG; Bian, J; Long, K; Chen, ZL
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 1997-08 |
| 卷号 | 63期号:4页码:296-298 |
| 关键词 | platelet activating factor PAF antagonist platelet aggregation piperbetol methylpiperbetol piperol A piperol B Piper betle Piperaceae |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-2006-957685 |
| 文献子类 | Article |
| 英文摘要 | Piperbetol, methylpiperbetol, piperol A, and piperol B, isolated from Piper betle, selectively inhibited the washed rabbit platelet aggregation induced by platelet activating factor (PAF) in a concentration-dependent manner. The IC50 values of piperbetol, methylpiperbetol, piperol A, piperol B, and ginkgolide B were about 18.2, 10.6, 114.2, 11.8, and 4.8 mu mol/l, respectively. The inhibitory potency of ginkgolide B was about 2.8, 1.2, 22.8, and 1.4 times higher than those of piperbetol, methylpiperbetol, piperol A, and piperol B, The concentration-response curve of PAF-induced platelet aggregation was shifted to the right by 50 mu mol/l of piperbetol, methylpiperbetol, piperol A, piperol B, and ginkgolide B. The EC50 of PAF was increased by these compounds from 1.5 nmol/l to 14.3, 23.1, 2.4, 20.6, and 47.2 mol/l, respectively. The compounds also inhibited the binding of [H-3]-PAF to washed rabbit platelets with IC50 values of 8.7, 5.3, 88, 6.2, and 1.8 mu mol/l. Correlating with the inhibitory potency for platelet aggregation, the inhibitory potency of ginkgolide B for binding of PAF was about 3.8, 1.9, 48, and 2.4 times higher than those of piperbetol, methylpiperbetol, piperol A, and piperol B. However, the aggregation of washed rabbit platelets induced by threshold ADP and arachidonic acid were unaffected by piperbetol, methylpiperbetol, piperol A, and piperol B. Furthermore, piperbetol, methylpiperbetol, piperol A, and piperol B had no effects on the cAMP contents in rest washed rabbit platelets, In conclusion, these data indicate that piperbetol, methylpierbetol, piperol A, and piperol B are effective PAF receptor antagonists in vitro. |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:A1997XQ45200002 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274893]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.ACAD SINICA, SHANGHAI INST MAT MED, SHANGHAI 200031, PEOPLES R CHINA 2.PHARM CTR NAVY, SHANGHAI 200081, PEOPLES R CHINA 3.Second Mil Med Univ, COLL PHARM, DEPT PHARMACOL, SHANGHAI 200433, PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Zeng, HW,Jiang, YY,Cai, DG,et al. Piperbetol, methylpiperbetol, piperol A and piperol B: A new series of highly specific PAF receptor antagonists from Piper betle[J]. PLANTA MEDICA,1997,63(4):296-298. |
| APA | Zeng, HW,Jiang, YY,Cai, DG,Bian, J,Long, K,&Chen, ZL.(1997).Piperbetol, methylpiperbetol, piperol A and piperol B: A new series of highly specific PAF receptor antagonists from Piper betle.PLANTA MEDICA,63(4),296-298. |
| MLA | Zeng, HW,et al."Piperbetol, methylpiperbetol, piperol A and piperol B: A new series of highly specific PAF receptor antagonists from Piper betle".PLANTA MEDICA 63.4(1997):296-298. |
入库方式： OAI收割
来源：上海药物研究所
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