Chiral phosphine ligands derived from sugars .10. Syntheses, structure, characterization, and antitumor activity of the gold(I) complexes with sugar-substructure phosphine ligands
文献类型：期刊论文
| 作者 | Shi, JC; Chen, LJ; Huang, XY; Wu, DX; Kang, BS |
| 刊名 | JOURNAL OF ORGANOMETALLIC CHEMISTRY
 |
| 出版日期 | 1997-05-15 |
| 卷号 | 535期号:1-2页码:17-23 |
| 关键词 | gold compound carbohydrate nuclear magnetic resonance X-ray diffraction chiral phosphine antitumor activity |
| ISSN号 | 0022-328X |
| DOI | 10.1016/S0022-328X(96)06947-1 |
| 文献子类 | Article |
| 英文摘要 | Gold(I) complexes with sugar-substructure phosphine ligands [Au(n-MBPA)L] [n-MBPA = methyl 4,6-O-benzylidene-n-deoxy-n-(diphenylphosphino)-alpha-D-altropyranoside, HL = 1H-pyrimidine-2-thione (2-pymSH), 3,5-dimethyl-1H-pyrimidine-2-thione (2-pymmSH). 1, n = 2, L = 2-pymS; 2, n = 3, L = 2-pymS; 3, n = 2, L = 2-pymmS; 4, n = 3, I, = 2-pymmS] have been prepared and characterized by H-1, C-13 and P-31 NMR and molecular vibration spectra. Compound 2 crystallizes in the orthorhombic space group P2(1)2(1)2(1) with a = 9.917(4), b = 14.418(6), c = 20.048(7)Angstrom, and Z = 4, R = 0.031 for 2493 reflections with I greater than or equal to 3 sigma(I). The mononuclear compound features a linear geometry for the gold atom defined by important parameters: Au-P 2.256(3)Angstrom, Au-S 2.306(3)Angstrom and P-Au-S 178.5(1)degrees. The altropyranose ring in 2 exhibits a distorted chair conformation. The preliminary experiment reveals that the gold(I) complexes with sugar-substructure phosphine ligands possess antitumor activity against P388 leukemia. (C) 1997 Elsevier Science S.A. |
| WOS关键词 | RAY CRYSTAL-STRUCTURE ; 1,3,5-TRIAZA-7-PHOSPHAADAMANTANE TPA ; SPECTROSCOPIC PROPERTIES ; RHEUMATOID-ARTHRITIS ; AURANOFIN ; COMPOUND ; P-31 ; LUMINESCENCE ; STATE ; AGENT |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:A1997XH95000003 |
| 出版者 | ELSEVIER SCIENCE SA LAUSANNE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274909]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Shi, JC |
| 作者单位 | 1.CHINESE ACAD SCI, FUJIAN INST RES STRUCT MATTER, FUZHOU 350002, FIJIAN, PEOPLES R CHINA 2.CHINESE ACAD SCI, SHANGHAI INST MED, SHANGHAI 210000, PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Shi, JC,Chen, LJ,Huang, XY,et al. Chiral phosphine ligands derived from sugars .10. Syntheses, structure, characterization, and antitumor activity of the gold(I) complexes with sugar-substructure phosphine ligands[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY,1997,535(1-2):17-23. |
| APA | Shi, JC,Chen, LJ,Huang, XY,Wu, DX,&Kang, BS.(1997).Chiral phosphine ligands derived from sugars .10. Syntheses, structure, characterization, and antitumor activity of the gold(I) complexes with sugar-substructure phosphine ligands.JOURNAL OF ORGANOMETALLIC CHEMISTRY,535(1-2),17-23. |
| MLA | Shi, JC,et al."Chiral phosphine ligands derived from sugars .10. Syntheses, structure, characterization, and antitumor activity of the gold(I) complexes with sugar-substructure phosphine ligands".JOURNAL OF ORGANOMETALLIC CHEMISTRY 535.1-2(1997):17-23. |
入库方式： OAI收割
来源：上海药物研究所
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