alpha-anordrin-induced apoptosis of leukemia K562 cells is not prevented by cicloheximide
文献类型：期刊论文
| 作者 | Lou, LG ; Xu, B
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1997-03 |
| 卷号 | 18期号:2页码:169-172 |
| 关键词 | alpha-anordrin cicloheximide leukemia K562 DNA damage cultured tumor cells |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study effect of protein synthesis inhibitor cicloheximide (Cic) on the apoptosis induced by alpha-anordrin (Ano) in leukemia K562 cells. METHODS: Morphological changes were observed by fluorescent microscopy. DNA content was measured by flow cytometry. DNA fragmentation Was analyzed by agarose gel electrophoresis. RESULTS: Exposure of K562 cells to Ano 50 mu mol . L(-1) for 24 h induced apoptotic cell death. Cic 1 mu mol . L(-1) did not abrogate or delay this effect. Indeed, Ano-induced apoptosis Was augmented by Cic. Cic 100 mu mol . L(-1) itself stimulated 25 % K562 cell apoptosis after 24-h culture. CONCLUSION: Ano-induced apoptosis was independent of de now, protein synthesis. |
| WOS关键词 | INDUCTION ; CYCLOHEXIMIDE ; LYMPHOCYTES ; INHIBITION ; GROWTH ; LINES |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:411917 |
| WOS记录号 | WOS:A1997WM32200020 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274921]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lou, LG |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | Lou, LG,Xu, B. alpha-anordrin-induced apoptosis of leukemia K562 cells is not prevented by cicloheximide[J]. ACTA PHARMACOLOGICA SINICA,1997,18(2):169-172. |
| APA | Lou, LG,&Xu, B.(1997).alpha-anordrin-induced apoptosis of leukemia K562 cells is not prevented by cicloheximide.ACTA PHARMACOLOGICA SINICA,18(2),169-172. |
| MLA | Lou, LG,et al."alpha-anordrin-induced apoptosis of leukemia K562 cells is not prevented by cicloheximide".ACTA PHARMACOLOGICA SINICA 18.2(1997):169-172. |
入库方式： OAI收割
来源：上海药物研究所
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