(-)-stepholidine enhances K+ depolarization-induced activation of synaptosomal tyrosine 3-monooxygenase from rat striatum
文献类型：期刊论文
| 作者 | Hu, G; Wu, YM; Jin, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1997-01 |
| 卷号 | 18期号:1页码:49-52 |
| 关键词 | depolarization tyrosine 3-monooxygenase protein kinases dopamine receptors stepholidine corpus striatum synaptosomes |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the mechanism of K+ depolarization-induced activation of synaptosomal tyrosine 3-monooxygenase (TM) the effect of (-)-stepholidine (SPD) on this activation. METHODS: The TM was assayed for DOPA by HPLC-ECD; the activities of Ca2+/calmodulin (CaM)-dependent protein kinase (PK II) and Ca2+/phosphoinositide-dependent protein. kinase (PKC) were assayed using histidine as substrate, RESULTS: The incubation of striatal synaptosomes in K+-riched (60 mmol . L(-1)) medium resulted in a marked activation of TM, PKC inhibitor polymyxin B (PMB) completely blocked the activation of K+ 60 mmol . L(-1) on TM, Selective D-2 receptor agonist quinpirole (QP), Ca2+ removal from incubation medium and CaM antagonist W7 failed to affect the activation, However, SPD enhanced the activation of K+ 60 mmol . L(-1) on TM, Meanwhile, the incubation in K+ 60 mmol . L(-1) also activated PKC, Neither QP nor SPD affected K+ depolarization-induced activation of PKC, CONCLUSION: The activation of K+ depolarization on synaptosomal TM is enhanced by SPD and this activation is mediated by PKC rather than by PK II. |
| WOS关键词 | HYDROXYLASE ; CALMODULIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1997WB88800009 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274937]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.XUZHOU MED COLL, NEUROPHARMACOL LAB, XUZHOU 221002, PEOPLES R CHINA 2.CHINESE ACAD SCI, SHANGHAI INST MAT MED, SHANGHAI 200031, PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Hu, G,Wu, YM,Jin, GZ. (-)-stepholidine enhances K+ depolarization-induced activation of synaptosomal tyrosine 3-monooxygenase from rat striatum[J]. ACTA PHARMACOLOGICA SINICA,1997,18(1):49-52. |
| APA | Hu, G,Wu, YM,&Jin, GZ.(1997).(-)-stepholidine enhances K+ depolarization-induced activation of synaptosomal tyrosine 3-monooxygenase from rat striatum.ACTA PHARMACOLOGICA SINICA,18(1),49-52. |
| MLA | Hu, G,et al."(-)-stepholidine enhances K+ depolarization-induced activation of synaptosomal tyrosine 3-monooxygenase from rat striatum".ACTA PHARMACOLOGICA SINICA 18.1(1997):49-52. |
入库方式： OAI收割
来源：上海药物研究所
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