Recent studies on traditional Chinese medicinal plants
文献类型：期刊论文
| 作者 | Zhu, DY; Bai, DL ; Tang, XC
|
| 刊名 | DRUG DEVELOPMENT RESEARCH
 |
| 出版日期 | 1996-10 |
| 卷号 | 39期号:2页码:147-157 |
| 关键词 | traditional Chinese medicinal plants huperzine A sarmentosin aconitum alkaloids |
| ISSN号 | 0272-4391 |
| 文献子类 | Article |
| 英文摘要 | This review will discuss several new drugs which were discovered and developed in recent years from traditional Chinese medicines by the Shanghai Institute of Materia Medica. Huperzine A was isolated from Huperzia serrata, a plant used for the treatment of contusion, strain, haematuria, and swelling in Chinese folk medicine. Pharmacological studies have indicated that huperzine A has powerful and reversible anticholinesterase activity. Y-maze methods have shown that huperzine A improves learning and retrieval processes, and facilitates memory retention. Huperzine A is used to treat patients with myasthenia gravis and Alzheimer's disease in China. Sarmentosin, a cyanogenic glucoside was isolated from the whole plant of Sedum sarmentosium. Th is plant has long been used to treat hepatitis by folk medicine. Sarmentosin significantly lowers the SGPT level of patients suffering from chronic viral hepatitis, and shows a suppressive effect on cell-mediated immune responses in mice. The root of Aconitum is well known in traditional Chinese medicine. Many Aconitum alkaloids have been isolated. Most show potent bioactivities, but with severe toxicity. Recently, some alkaloids such as 3-acetylaconitine, appaconitine, have shown significant anesthetic activity and exhibit a higher therapeutic index. Guan-fu base A was isolated from the tuber root of Aconitum coreanum. Guan-fu base A has antiarrhythmic action and is now in clinical trials. (C) 1997 Wiley-Liss, Inc. |
| WOS关键词 | TABLET HUPERZINE-A ; DISCRIMINATION PERFORMANCE ; N-DEACETYLLAPPACONITINE ; ANALGESIC ACTION ; MEMORY ; CHOLINESTERASE ; LAPPACONITINE ; RATS ; 3-ACETYLACONITINE ; PHARMACOKINETICS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1996WL63800006 |
| 出版者 | WILEY-LISS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274955]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhu, DY |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | Zhu, DY,Bai, DL,Tang, XC. Recent studies on traditional Chinese medicinal plants[J]. DRUG DEVELOPMENT RESEARCH,1996,39(2):147-157. |
| APA | Zhu, DY,Bai, DL,&Tang, XC.(1996).Recent studies on traditional Chinese medicinal plants.DRUG DEVELOPMENT RESEARCH,39(2),147-157. |
| MLA | Zhu, DY,et al."Recent studies on traditional Chinese medicinal plants".DRUG DEVELOPMENT RESEARCH 39.2(1996):147-157. |
入库方式： OAI收割
来源：上海药物研究所
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