Blockade of (+/-)12-chloroscoulerine on feed-back regulation of dopamine D-2 autoreceptors
文献类型：期刊论文
| 作者 | Chen, LJ; Zhang, XX ; Guo, X
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1996-09 |
| 卷号 | 17期号:5页码:477-480 |
| 关键词 | (+/-)12-chloroscoulerine berbines levodopa dopamine autoreceptors substantia nigra corpus striatum |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | To verify whether (+/-)12-chloroscoulerine (CSL) is antagonist or agonist effect to D-2 autoreceptors. METHODS: The levodopa content accumulated in the rat striatum was measured by HPLC-ECD, and the DA neuron firing activity in the substantia nigra zona compacta (SNC) was recorded. RESULTS: The accumulated levodopa content induced by CSL 40 mg . kg(-1) was much more than that of 1,4-butyro-lactone (BL) group (P<0.01). After ip injection of apomorphine (Ape) 5 mg . kg(-1), the levodopa content was decreased below that of BL group (P<0.05). The Apo inhibition on levodopa content was completely reversed by CSL (40 mg . kg(-1), ip) and then increased the levodopa content (2.5+/-1.1 mu g . g(-1)) over that of Apo group (0.7+/-0.3 mu g . g(-1), P<0.01). In the electrophysiologic recording, Apo (15 mu g . kg(-1), iv) induced the decrease of SNC DA cell firing rate nearly to zero. At the accumulated dose of CSL up to 80 mu g . kg(-1) (iv), the inhibition of Apo was attenuated and the firing activity was restored to predrug level. CONCLUSION: CSL showed an antagonistic action, an action to D-2 autoreceptors. |
| WOS关键词 | L-STEPHOLIDINE ; ROTATIONAL BEHAVIOR ; RECEPTORS ; TETRAHYDROPROTOBERBERINES ; ANTAGONIST ; RATS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| WOS记录号 | WOS:A1996VF91900026 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274961]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, LJ |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | Chen, LJ,Zhang, XX,Guo, X. Blockade of (+/-)12-chloroscoulerine on feed-back regulation of dopamine D-2 autoreceptors[J]. ACTA PHARMACOLOGICA SINICA,1996,17(5):477-480. |
| APA | Chen, LJ,Zhang, XX,&Guo, X.(1996).Blockade of (+/-)12-chloroscoulerine on feed-back regulation of dopamine D-2 autoreceptors.ACTA PHARMACOLOGICA SINICA,17(5),477-480. |
| MLA | Chen, LJ,et al."Blockade of (+/-)12-chloroscoulerine on feed-back regulation of dopamine D-2 autoreceptors".ACTA PHARMACOLOGICA SINICA 17.5(1996):477-480. |
入库方式： OAI收割
来源：上海药物研究所
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