D-1 dopamine receptor stimulation inhibits firing activity of midbrain dopamine neurons in reserpine treated rats: An effect eliminated after hemitransection of diencephalon
文献类型：期刊论文
| 作者 | Sun, BC; Chouvet, G; Jin, GZ
|
| 刊名 | SYNAPSE
 |
| 出版日期 | 1996-09 |
| 卷号 | 24期号:1页码:29-38 |
| 关键词 | dopamine neurons D-1 dopamine receptors reserpine supersensitivity substantia nigra pars compacta substantia nigra pars reticulata ventral tegmental area |
| ISSN号 | 0887-4476 |
| 文献子类 | Article |
| 英文摘要 | It has been reported that systemic administration of the D-1 dopamine (DA) receptor agonist SKF 38393 inhibits the firing rate of substantia nigra pars compacta (SNC, A9) DA neurons after repeated reserpine treatment in locally anesthetized rats, although SKF 38393 induces little effect on the firing of midbrain DA neurons in normal rats. The present study found that local pressure microejection of SKF 38393 (10(-2) M, 20-100 nl) to SNC or substantia nigra pars reticulata (SNR) failed to influence the firing of SNC DA neurons in reserpinized rats (reserpine 1 mg/kg x 6 days, s.c.); subsequent intravenous (i.v.) injection of SKF 38393 (4 mg/kg), however, inhibited their firing and the inhibition was reversed by the D-1 receptor antagonist SCH 23390. Similarly, systemic administration of SKF 38393 (4 mg/kg, i.v.) inhibited the firing of ventral tegmental area (VTA, A10) DA cells in reserpinized rats, while local microejection of SKF 38393 (10(-2) M, 30-60 nl) did not affect their firing. Furthermore, the inhibitory effect of systemic SKF 38393 on firing rate of either SNC or VTA DA neurons in reserpinized rats was eliminated after hemitransection of diencephalon. These results suggest that repeated reserpine treatment renders midbrain DA neurons responsive to D-1 receptor stimulation and that D, receptor agonist-induced inhibition of midbrain DA cell firing in reserpinized rats may require the involvement of long-loop feedback pathways. (C) 1996 Wiley-Liss, Inc. |
| WOS关键词 | VENTRAL TEGMENTAL AREA ; SUBSTANTIA-NIGRA ; D1 RECEPTORS ; MEDIATED INHIBITION ; CELL-ACTIVITY ; SKF 38393 ; AGONISTS ; BRAIN ; EXPRESSION ; ALTERS |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:A1996VE04400004 |
| 出版者 | WILEY-LISS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274962]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.CTR HOSP LYON SUD,INSERM U171,F-69310 PIERRE BENITE,FRANCE 2.CTR HOSP LYON SUD,CNRS URA 1195,F-69310 PIERRE BENITE,FRANCE 3.CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL 2,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Sun, BC,Chouvet, G,Jin, GZ. D-1 dopamine receptor stimulation inhibits firing activity of midbrain dopamine neurons in reserpine treated rats: An effect eliminated after hemitransection of diencephalon[J]. SYNAPSE,1996,24(1):29-38. |
| APA | Sun, BC,Chouvet, G,&Jin, GZ.(1996).D-1 dopamine receptor stimulation inhibits firing activity of midbrain dopamine neurons in reserpine treated rats: An effect eliminated after hemitransection of diencephalon.SYNAPSE,24(1),29-38. |
| MLA | Sun, BC,et al."D-1 dopamine receptor stimulation inhibits firing activity of midbrain dopamine neurons in reserpine treated rats: An effect eliminated after hemitransection of diencephalon".SYNAPSE 24.1(1996):29-38. |
入库方式： OAI收割
来源：上海药物研究所
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