Antagonism of l-stepholidine against bromocriptine-inhibition on prolactin level in lactational rats
文献类型：期刊论文
| 作者 | You, CL; Han, ZF; Qu, YS; Wang, YM; Chen, LJ; Jin, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1996-07 |
| 卷号 | 17期号:4页码:382-384 |
| 关键词 | l-stepholidine bromocriptine prolactin dopamine D-2 receptors lactation |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the antagonism of l-stepholidine (SPD) against bromocriptine (Bro)-inhibition on prolactin (PRL) level. METHODS: Bro (0.5 mg . kg(-1) . d(-1), sc) reduced the PRL and caused a dysplasia of mammary gland in lactational rats. The weight growing of newborn rats was retarded. The PRL of the lactational rats was assessed by immunoradiometric assay (IRMA); the weight of newborn rats and development of mammary glands in lactational rats were also examined. Antagonism of SPD was evaluated. RESULTS: SPD (30 & 100 mg . kg(-1) . d(-1), ip) obviously antagonized the Bro that induced lowering the PRL level in lactational rats, the PRL was 11+/-4 & 23 +/- 6 mu g . L(-1) (NS 7 +/- 2) respectively on d 15 of postpartum and the development of mammary gland in lactational rats was normal. The newborn rats grew rapidly in 11-15 d. CONCLUSION: SPD possessed an antagonism with Bro inhibition on D-2 receptors located in the pituitary gland, and was an antagonist of dopamine D-2 receptors. |
| WOS关键词 | MAMMARY-GLAND ; (-)-STEPHOLIDINE ; LIVER |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:940147 |
| WOS记录号 | WOS:A1996UW39400028 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274968]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | You, CL |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | You, CL,Han, ZF,Qu, YS,et al. Antagonism of l-stepholidine against bromocriptine-inhibition on prolactin level in lactational rats[J]. ACTA PHARMACOLOGICA SINICA,1996,17(4):382-384. |
| APA | You, CL,Han, ZF,Qu, YS,Wang, YM,Chen, LJ,&Jin, GZ.(1996).Antagonism of l-stepholidine against bromocriptine-inhibition on prolactin level in lactational rats.ACTA PHARMACOLOGICA SINICA,17(4),382-384. |
| MLA | You, CL,et al."Antagonism of l-stepholidine against bromocriptine-inhibition on prolactin level in lactational rats".ACTA PHARMACOLOGICA SINICA 17.4(1996):382-384. |
入库方式： OAI收割
来源：上海药物研究所
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