Anti-alpha-fetoprotein activity of L-4-oxalysine
文献类型：期刊论文
| 作者 | Wang, XW; Xu, B
|
| 刊名 | ASIA PACIFIC JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 1996-06 |
| 卷号 | 11期号:2页码:25-28 |
| 关键词 | oxalysine 5-fluorouracil alpha-fetoprotein mouse ascites hepatoma-22 (H-22) cells suppressor T cells MTT-microculture tetrazolium assay one-way mixed lymphocyte reactions |
| ISSN号 | 0217-9687 |
| 文献子类 | Article |
| 英文摘要 | Effect of L-4-oxalysine (OXL) on the growth stimulatory action and Ts cell induc tion activity of alpha-fetoprotein (AFP) was studied in vitro. When compared with 5-fluorouracil (5-FU), single treatment of OXL presented a weaker cytotoxic activity against mouse ascites hepatoma-22 (H-22) cells. Moreover, lower concentrations of OXL (less than 25 mu g ml(-1)) had no marked antagonistic action on the growth stimulation of H-22 cells by AFP (100 mu g ml(-1)). But, higher concentrations of OXL (25-100 mu g ml(-1)) could significantly abolish the action of AFP. On the other side, when 12.5 mu g ml(-1) of OXL was used in combination with 3.1 mu g ml(-1) of 5-FU, the percentage of suppression on hepatoma growth stimulated by AFP (50 mu g ml(-1)) was increased to 42.8% from 8.3% (OXL alone) or 20.2% (5-FU alone). When 25 mu g ml(-1) of OXL was combined with 6.3 mu g ml(-1) of 5-FU, the inhibition percentage was increased to 63.1% from 35.7% (OXL alone) or 48.8% (5-FU alone). In addition, it was observed by one-way mixed lymphocyte reactions that OXL (12.5 or 50 mu g ml(-1)) produced an inhibitory action on the activity of suppressor T cells induced by AFP (200 mu g ml(-1)). |
| WOS关键词 | CELLS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1996VV18100001 |
| 出版者 | SINGAPORE UNIV PRESS UNIV SINGAPORE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274976]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, XW |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | Wang, XW,Xu, B. Anti-alpha-fetoprotein activity of L-4-oxalysine[J]. ASIA PACIFIC JOURNAL OF PHARMACOLOGY,1996,11(2):25-28. |
| APA | Wang, XW,&Xu, B.(1996).Anti-alpha-fetoprotein activity of L-4-oxalysine.ASIA PACIFIC JOURNAL OF PHARMACOLOGY,11(2),25-28. |
| MLA | Wang, XW,et al."Anti-alpha-fetoprotein activity of L-4-oxalysine".ASIA PACIFIC JOURNAL OF PHARMACOLOGY 11.2(1996):25-28. |
入库方式： OAI收割
来源：上海药物研究所
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