Effect of (+/-)12-chloroscoulerine on brain dopamine receptors
文献类型：期刊论文
| 作者 | Chen, LJ; Xi, Y; Pang, DW; Zhou, QT; Jin, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1996-03 |
| 卷号 | 17期号:2页码:185-189 |
| 关键词 | (+/-)12-chloroscoulerine dopamine receptors (-)stepholidine catalepsy stereotyping |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To assess potencies of tetrahydroprotoberberines (THPB) and hydrobenzyltetrahydroisoquinolines (HBTI) on DA receptors. METHODS: The receptor binding assay with calf striatum to D-1 and D-2 receptors, and the animal behavior tests were used. RESULTS: (+/-)12-Chloroscoulerine (CSL) was the most potent one among the THPB and HBTI. The affinities of CSL to D-1 and D-2 receptors were 13 and 51 nmol L(-1), respectively, in rats, CSL showed an antagonistic effect on the stereotypy and induced catalepsy. In the 6-OHDA lesioned rats, however, CSL exerted the agonistic effect to DA receptors. CONCLUSION: CSL had dual actions to DA receptors and its effects were similar to that of (-)stepholidine. |
| WOS关键词 | ROTATIONAL BEHAVIOR ; L-STEPHOLIDINE ; TETRAHYDROPROTOBERBERINES ; RATS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:339724 |
| WOS记录号 | WOS:A1996TZ76400025 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274995]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, LJ |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | Chen, LJ,Xi, Y,Pang, DW,et al. Effect of (+/-)12-chloroscoulerine on brain dopamine receptors[J]. ACTA PHARMACOLOGICA SINICA,1996,17(2):185-189. |
| APA | Chen, LJ,Xi, Y,Pang, DW,Zhou, QT,&Jin, GZ.(1996).Effect of (+/-)12-chloroscoulerine on brain dopamine receptors.ACTA PHARMACOLOGICA SINICA,17(2),185-189. |
| MLA | Chen, LJ,et al."Effect of (+/-)12-chloroscoulerine on brain dopamine receptors".ACTA PHARMACOLOGICA SINICA 17.2(1996):185-189. |
入库方式： OAI收割
来源：上海药物研究所
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