Multicenter clinical trial on the efficacy and acceptability of a single contraceptive implant of nomegestrol acetate, Uniplant
文献类型：期刊论文
| 作者 | Coutinho, EM; deSouza, JC; Athayde, C; Barbosa, IC; Alvarez, F; Brache, V; Gu, ZP; Emuveyan, EE; Adekunle, AO; Devoto, L |
| 刊名 | CONTRACEPTION
 |
| 出版日期 | 1996-02 |
| 卷号 | 53期号:2页码:121-125 |
| 关键词 | single contraceptive implant Uniplant |
| ISSN号 | 0010-7824 |
| DOI | 10.1016/0010-7824(95)00263-4 |
| 文献子类 | Article |
| 英文摘要 | Uniplant, a single Silastic implant containing nomegestrol acetate, provides contraceptive efficacy for one year. Uniplant use for one year was studied in 1,803 healthy women of reproductive age, enrolled from 10 centers in 9 countries, after informed consent. Implants were placed subdermally either in the upper arm or in the gluteal region. Two-hundred-seventy-six subjects discontinued prior to completing one year of study. Cumulative discontinuation rate at 12 months was 15.72%. Medical reasons for discontinuation were principally menstrual-related. Fifteen pregnancies occurred during the one year study period, resulting in a 12-month net cumulative pregnancy rate of 0.94%. Approximately 56% of subjects using Uniplant had bleeding patterns similar to normal menstruation. Results from this study confirm that Uniplant is an efficient, well tolerated, 12-month contraceptive implant, with the advantage of easier insertion and removal of the single implant compared to other multiple implant methods. |
| WOS研究方向 | Obstetrics & Gynecology |
| 语种 | 英语 |
| WOS记录号 | WOS:A1996TU68700009 |
| 出版者 | BUTTERWORTH-HEINEMANN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275003]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Coutinho, EM |
| 作者单位 | 1.SOUTH SOUTH COOPERAT REPROD HLTH,SALVADOR,BA,BRAZIL 2.KENYA GOVT MED RES CTR,REPROD HLTH RES UNIT,NAIROBI,KENYA 3.PROFAMILIA,SANTO DOMINGO,DOMINICAN REP 4.SHANGHAI INST MAT MED,SHANGHAI,PEOPLES R CHINA 5.UNIV LAGOS,COLL MED,DEPT OBSTET & GYNECOL,LAGOS,NIGERIA 6.UNIV IBADAN,UNIV COLL HOSP,DEPT OBSTET & GYNECOL,IBADAN,NIGERIA 7.UNIV CHILE,FAC MED,DEPT OBSTET & GYNECOL,SANTIAGO 7,CHILE 8.UNIV ASSIUT,SCH MED,DEPT OBSTET & GYNECOL,ASSIUT,EGYPT 9.UNIV INDONESIA,FAC MED,DEPT OBSTET & GYNECOL,JAKARTA,INDONESIA 10.INST NACL ENDOCRINOL,HAVANA,CUBA |
| 推荐引用方式 GB/T 7714 | Coutinho, EM,deSouza, JC,Athayde, C,et al. Multicenter clinical trial on the efficacy and acceptability of a single contraceptive implant of nomegestrol acetate, Uniplant[J]. CONTRACEPTION,1996,53(2):121-125. |
| APA | Coutinho, EM.,deSouza, JC.,Athayde, C.,Barbosa, IC.,Alvarez, F.,...&Ladipo, OA.(1996).Multicenter clinical trial on the efficacy and acceptability of a single contraceptive implant of nomegestrol acetate, Uniplant.CONTRACEPTION,53(2),121-125. |
| MLA | Coutinho, EM,et al."Multicenter clinical trial on the efficacy and acceptability of a single contraceptive implant of nomegestrol acetate, Uniplant".CONTRACEPTION 53.2(1996):121-125. |
入库方式： OAI收割
来源：上海药物研究所
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