AUGMENTATION OF DOPAMINE RELEASE BY (-)-STEPHOLIDINE FROM RABBIT AND RAT CAUDATE SLICES
文献类型：期刊论文
| 作者 | DONG, ZJ; JIN, GZ ; HUANG, HY
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1995-11 |
| 卷号 | 16期号:6页码:497-501 |
| 关键词 | BERBINES PHORBOL 12, 13-DIBUTYRATE CAUDATE NUCLEUS DOPAMINE D-2 RECEPTORS PROTEIN KINASE C (-)-STEPHOLIDINE |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effect of (-)-stepholidine (SPD) on dopamine (DA) release evoked by electric stimulation on slices of rabbit caudate nucleus. METHODS: Slices of rabbit caudate nucleus were preincubated with [H-3]DA and then perfused and stimulated electrically, RESULTS: Quinpirole (Qui), a selective DA D-2 receptor agonist, reduced [H-3]DA overflow elicited by 24 mA electric stimulation (IC50 = 0.12, 95 % confidence limits 0.09 - 0.17 mu mol L(-1)). SPD markedly increased the potential of the stimulation-evoked [H-3] DA overflow in a dose-dependent manner and reversed Qui (1 mu mol . L(-1))-induced attenuation of [H-3]DA release. The pA(2) value calculated from the data of [H-3]DA overflow for SPD was 7.495. In the experiments with rat caudate nucleus slices, SPD (0.1 mmol . L(-1)) increased the [H-3]DA outflow from 3.3+/-0.2 % to 6.5+/-0.5 % of the tissue [H-3]DA content, which was further enhanced by the protein kinase C (PKC) activator phorbol 12,13-dibutyrate (PDB, 1 mu mol . L(-1)) to 10.1+/-1.0 % of the total [H-3]DA in the tissue. CONCLUSION: SPD is a presynaptic D-2 autoreceptor antagonist and induces a synergic effect on [H-3]DA release process with PKC. |
| WOS关键词 | L-STEPHOLIDINE ; NORADRENALINE RELEASE ; CORPUS STRIATUM ; PHORBOL ESTER ; TETRAHYDROPROTOBERBERINES ; RECEPTORS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1995TE37500005 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275022]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.CHINESE ACAD SCI,SHANGHAI INST PHYSIOL,SHANGHAI 200031,PEOPLES R CHINA 2.CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | DONG, ZJ,JIN, GZ,HUANG, HY. AUGMENTATION OF DOPAMINE RELEASE BY (-)-STEPHOLIDINE FROM RABBIT AND RAT CAUDATE SLICES[J]. ACTA PHARMACOLOGICA SINICA,1995,16(6):497-501. |
| APA | DONG, ZJ,JIN, GZ,&HUANG, HY.(1995).AUGMENTATION OF DOPAMINE RELEASE BY (-)-STEPHOLIDINE FROM RABBIT AND RAT CAUDATE SLICES.ACTA PHARMACOLOGICA SINICA,16(6),497-501. |
| MLA | DONG, ZJ,et al."AUGMENTATION OF DOPAMINE RELEASE BY (-)-STEPHOLIDINE FROM RABBIT AND RAT CAUDATE SLICES".ACTA PHARMACOLOGICA SINICA 16.6(1995):497-501. |
入库方式： OAI收割
来源：上海药物研究所
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