GABA(A) RECEPTOR-MEDIATED FEEDBACK INHIBITION IN PYRAMIDAL NEURONS OF CAT MOTOR CORTEX
文献类型：期刊论文
| 作者 | CHEN, W; ZHANG, JJ; HU, GY; WU, CP |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 1995-09-29 |
| 卷号 | 198期号:2页码:123-126 |
| 关键词 | FEEDBACK INHIBITION GAMMA-AMINOBUTYRIC ACID GABA(A) RECEPTOR RECURRENT COLLATERAL PYRAMIDAL NEURON MOTOR CORTEX CAT |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/0304-3940(95)11993-7 |
| 文献子类 | Article |
| 英文摘要 | Feedback or recurrent inhibition is generally proposed as a basic component of circuit organization in the brain. However, there is little direct evidence for its existence in the cortex, nor for the nature of the neurotransmitters and receptors involved. Here we address this issue by analyzing the potentials following a single action potential in cat neocortical pyramidal neurons. Using 3 M KCl-filled electrodes, we observed a distinct depolarizing potential that was superimposed on the spike after-potentials in seven out of 81 recorded neurons. This depolarizing potential had a latency of 4.4 +/- 1.6 ms and an amplitude of 4.8 +/- 2.1 mV. Its short risetime (1.39 +/- 0.27 ms) and the resemblance between its falling phase and the passive decay of membrane potential suggested that the depolarizing potential originated from the cell body or proximal dendrites. This potential was blocked by bicuculline methiodide (10 mu M), but not by phaclofen (0.2mM), suggesting that it was a reversed recurrent IPSP mediated by GABA(A) receptors. |
| WOS关键词 | POSTSYNAPTIC POTENTIALS ; CELLS ; INTERNEURONS ; STIMULATION ; PATHWAYS ; INVITRO |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:A1995TA40600014 |
| 出版者 | ELSEVIER SCI PUBL IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275025]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA 2.CHINESE ACAD SCI,SHANGHAI BRAIN RES INST,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | CHEN, W,ZHANG, JJ,HU, GY,et al. GABA(A) RECEPTOR-MEDIATED FEEDBACK INHIBITION IN PYRAMIDAL NEURONS OF CAT MOTOR CORTEX[J]. NEUROSCIENCE LETTERS,1995,198(2):123-126. |
| APA | CHEN, W,ZHANG, JJ,HU, GY,&WU, CP.(1995).GABA(A) RECEPTOR-MEDIATED FEEDBACK INHIBITION IN PYRAMIDAL NEURONS OF CAT MOTOR CORTEX.NEUROSCIENCE LETTERS,198(2),123-126. |
| MLA | CHEN, W,et al."GABA(A) RECEPTOR-MEDIATED FEEDBACK INHIBITION IN PYRAMIDAL NEURONS OF CAT MOTOR CORTEX".NEUROSCIENCE LETTERS 198.2(1995):123-126. |
入库方式： OAI收割
来源：上海药物研究所
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