TOXICITY OF DOPAMINE TO MOUSE NEUROBLASTOMA-X RAT GLIOMA HYBRID (NG108) CELLS IN-VITRO
文献类型：期刊论文
| 作者 | WANG, RG; ZHU, XZ |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1995-07 |
| 卷号 | 16期号:4页码:294-296 |
| 关键词 | DOPAMINE NEUROBLASTOMA GLIOMA CULTURED CELLS CELL SURVIVAL SULPIRIDE SCH-23390 CATALASE SUPEROXIDE DISMUTASE |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study toxicity of dopamine to mouse neuroblastoma X rat glioma hybrid (NG108) cells. METHODS: Cell viability was estimated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. RESULTS: Dopamine at 100 mu mol L(-1) was toxic when added to cultures 24 h after plating. The cell viability was about 1/4 of control. Toxicity did not seem to be mediated by dopaminergic receptors because the dopaminergic antagonists sulpiride and Sch-23390 did not block the toxic effect of dopamine. Catalase 50 kU L(-1), superoxide dismutase 50 kU L(-1) and l-ascorbic acid 200 mu mol L(-1) blocked the dopamine (125 mu mol L(-1)) toxicity and elevated the cell viability from 25.9 +/- 11.0 % to 74.8 +/- 4.4 %, 72.3 +/- 4.5 % and 71.4 +/- 2.3 %, respectively. CONCLUSION: Dopamine toxicity to NG108 cells was mainly attributed to the oxidation of dopamine and its toxic by-products, eg, H2O2. |
| WOS关键词 | ISCHEMIA ; MICRODIALYSIS ; NEUROTOXICITY ; GLUTAMATE ; STRIATUM |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:288307 |
| WOS记录号 | WOS:A1995RJ09600002 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275037]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | WANG, RG |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL 1,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | WANG, RG,ZHU, XZ. TOXICITY OF DOPAMINE TO MOUSE NEUROBLASTOMA-X RAT GLIOMA HYBRID (NG108) CELLS IN-VITRO[J]. ACTA PHARMACOLOGICA SINICA,1995,16(4):294-296. |
| APA | WANG, RG,&ZHU, XZ.(1995).TOXICITY OF DOPAMINE TO MOUSE NEUROBLASTOMA-X RAT GLIOMA HYBRID (NG108) CELLS IN-VITRO.ACTA PHARMACOLOGICA SINICA,16(4),294-296. |
| MLA | WANG, RG,et al."TOXICITY OF DOPAMINE TO MOUSE NEUROBLASTOMA-X RAT GLIOMA HYBRID (NG108) CELLS IN-VITRO".ACTA PHARMACOLOGICA SINICA 16.4(1995):294-296. |
入库方式： OAI收割
来源：上海药物研究所
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