METHIONINE-ENKEPHALIN AUGMENTS INTERLEUKIN-6 PRODUCTION AND GENE-EXPRESSION
文献类型：期刊论文
| 作者 | ZHONG, F; LI, XY; YANG, SL |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1995-05 |
| 卷号 | 16期号:3页码:205-209 |
| 关键词 | METHIONINE-ENKEPHALIN INTERLEUKIN-6 GENE EXPRESSION MESSENGER RNA CULTURED CELLS |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effect of methionine-enkephalin (met-enk) on the production and gene expression of interleukin-6 (IL-6) both in vivo and in vitro. METHODS: IL-6 was assayed using its dependent cell line MH60 . BSF2 and measured by MTT spectrophotometry. IL-6 gene expression was proceeded by RNA isolation and hybridization with IL-6 cDNA. RESULTS: Met-enk stimulated IL-6 mRNA expression and increased its stability. Met-enk 0.1 and 1 mg . kg(-1) ip for 6 d enhanced serum IL-6 levels. CONCLUSION: An up-regulation of IL-6 by met-enk was mediated through an increase in transcriptional activity and stability of IL-6 mRNA. |
| WOS关键词 | TRANSCRIPTION FACTOR ; CELLS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1995QX83200004 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275051]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA 2.CHINESE ACAD SCI,SHANGHAI RES CTR BIOTECHNOL,SHANGHAI 200233,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | ZHONG, F,LI, XY,YANG, SL. METHIONINE-ENKEPHALIN AUGMENTS INTERLEUKIN-6 PRODUCTION AND GENE-EXPRESSION[J]. ACTA PHARMACOLOGICA SINICA,1995,16(3):205-209. |
| APA | ZHONG, F,LI, XY,&YANG, SL.(1995).METHIONINE-ENKEPHALIN AUGMENTS INTERLEUKIN-6 PRODUCTION AND GENE-EXPRESSION.ACTA PHARMACOLOGICA SINICA,16(3),205-209. |
| MLA | ZHONG, F,et al."METHIONINE-ENKEPHALIN AUGMENTS INTERLEUKIN-6 PRODUCTION AND GENE-EXPRESSION".ACTA PHARMACOLOGICA SINICA 16.3(1995):205-209. |
入库方式： OAI收割
来源：上海药物研究所
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