BINDING-SITES OF ZNC(C)PR, A PENTAPEPTIDE FRAGMENT OF ARGIPRESSIN, IN RAT-BRAIN
文献类型：期刊论文
| 作者 | WU, JH; DU, YC |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1995-03 |
| 卷号 | 16期号:2页码:141-144 |
| 关键词 | ZNC(C)PR NEUROPEPTIDES NEUROPEPTIDE RECEPTORS BRAIN RADIOLIGAND ASSAY |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the binding sites of ZNC(C)PR, a C-terminal pentapeptide fragment of argipressin, in rat brain. METHODS: Using radioligand assay and radioligand [S-35]ZNC(C)PR. RESULTS: It was found that there exist native binding sites bound ZNC(C)PR with high affinity in a saturable, reversible and specific manner. Scatchard and kinetic analyses showed that these sites were homogeneous with a K-d value of 1.69 +/- 0.16 nmol . L(-1) (in the presence of MgCl2 10 mmol . L(-1)). The binding of ZNC(C)PR to the sites was at a higher level in the brain regions (such as amygdala, cortex,) and was affected by Mg2+. CONCLUSION: These binding sites represented a new type of receptors and mediated the action of ZNC(C)PR on memory. |
| WOS关键词 | ARGININE-VASOPRESSIN ; AVOIDANCE ; OXYTOCIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1995QM01800011 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275059]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | WU, JH |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST BIOCHEM,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | WU, JH,DU, YC. BINDING-SITES OF ZNC(C)PR, A PENTAPEPTIDE FRAGMENT OF ARGIPRESSIN, IN RAT-BRAIN[J]. ACTA PHARMACOLOGICA SINICA,1995,16(2):141-144. |
| APA | WU, JH,&DU, YC.(1995).BINDING-SITES OF ZNC(C)PR, A PENTAPEPTIDE FRAGMENT OF ARGIPRESSIN, IN RAT-BRAIN.ACTA PHARMACOLOGICA SINICA,16(2),141-144. |
| MLA | WU, JH,et al."BINDING-SITES OF ZNC(C)PR, A PENTAPEPTIDE FRAGMENT OF ARGIPRESSIN, IN RAT-BRAIN".ACTA PHARMACOLOGICA SINICA 16.2(1995):141-144. |
入库方式： OAI收割
来源：上海药物研究所
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