EFFECTS OF ISOVANIHUPERZINE-A ON CHOLINESTERASE AND SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT
文献类型：期刊论文
| 作者 | XIONG, ZQ; TANG, XC ; LIN, JL; ZHU, DY
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1995-01 |
| 卷号 | 16期号:1页码:21-25 |
| 关键词 | HUPERZINE A ISOVANIHUPERZINE A PHYSOSTIGMINE GALANTHAMINE CHOLINESTERASE INHIBITORS SCOPOLAMINE ISOFLUROPHATE COGNITION DISORDERS MEMORY |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effects of isovanihuperzine A (IVHA) on cholinesterase and scopolamine-induced memory deficit. METHODS: AChE and BuChE activities were determined by the colorimetric method of Ellman. The K-i value was determined by the plotting method of Lineweaver and Burk. In a behavioral test, rats were trained to perform a radial arm maze task using a partially baited procedure. RESULTS: The anti-AChE activity of IVHA was comparable to huperzine A (Hup-A), and was more potent than those of physostigmine and galanthamine with an IC50 value of 0. 11 mu mol . L(-1). IVHA was a mixed competitive type with a K-i value of 32 nmol . L(-1). It bound to AChE in a reversible man ner. IVHA at a dose of 0. 2 mg . kg(-1) ip significantly reversed scopolamine-induced working memory and reference memory impairments in radial arm maze. CONCLUSION: IVHA is a new potential reversible AChE inhibitor and merits further study as a cognitive enhancer. |
| WOS关键词 | HUPERZINE-A |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| WOS记录号 | WOS:A1995QB49300002 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275072]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | XIONG, ZQ |
| 作者单位 | CHINESE ACAD PREVENT MED, SHANGHAI INST MAT MED, DEPT PHYTOCHEM, SHANGHAI 200031, PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | XIONG, ZQ,TANG, XC,LIN, JL,et al. EFFECTS OF ISOVANIHUPERZINE-A ON CHOLINESTERASE AND SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT[J]. ACTA PHARMACOLOGICA SINICA,1995,16(1):21-25. |
| APA | XIONG, ZQ,TANG, XC,LIN, JL,&ZHU, DY.(1995).EFFECTS OF ISOVANIHUPERZINE-A ON CHOLINESTERASE AND SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT.ACTA PHARMACOLOGICA SINICA,16(1),21-25. |
| MLA | XIONG, ZQ,et al."EFFECTS OF ISOVANIHUPERZINE-A ON CHOLINESTERASE AND SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT".ACTA PHARMACOLOGICA SINICA 16.1(1995):21-25. |
入库方式： OAI收割
来源：上海药物研究所
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