EFFECT OF DIMERCAPTOSUCCINIC ACID PER-OS ON DISTRIBUTION AND EXCRETION OF PB-210 AND HG-203 IN MICE
文献类型：期刊论文
| 作者 | LIANG, YY; ZHANG, JS; TAO, ZQ; YAN, XM; XU, XH; CHEN, ZJ |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1994-07 |
| 卷号 | 15期号:4页码:379-382 |
| 关键词 | DIMERCAPTOSUCCINIC ACID LEAD RADIOISOTOPES MERCURY RADIOISOTOPES URINE TISSUE DISTRIBUTION BICARBONATES CITRATES COMBINATION DRUG THERAPY |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Sodium dimercaptosuccinate (Na-DMS) ip 1 g . kg(-1), dimercaptosuccinic acid (DMSA) ig 1 g . kg(-1), DMSA ig 1 g . kg(-1) with NaHCO3 or Na-citrate ig 3 g . kg(-1) was given to mice, separately. It enhanced the excretion of Pb-210 in urine about 3.4, 3.8, 3.6, and 2.3 times vs control, respectively within 24 h. It enhanced the excretion of Hg-203 in urine about 2.4, 2.3, 3. 3, and 2.7 times, respectively within 24 h. Fecal excretion was not significantly elevated vs control. Tissue radioactivities showed a remarkable decrease in the levels of Pb-210 and Hg-203 in most organs, but DMSA increase the Pb-210 content in kidney. The therapeutic effect of ig DMSA was similar to that of ip sodium dimercaptosuccinate. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:255064 |
| WOS记录号 | WOS:A1994NW64600024 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275094]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | LIANG, YY |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | LIANG, YY,ZHANG, JS,TAO, ZQ,et al. EFFECT OF DIMERCAPTOSUCCINIC ACID PER-OS ON DISTRIBUTION AND EXCRETION OF PB-210 AND HG-203 IN MICE[J]. ACTA PHARMACOLOGICA SINICA,1994,15(4):379-382. |
| APA | LIANG, YY,ZHANG, JS,TAO, ZQ,YAN, XM,XU, XH,&CHEN, ZJ.(1994).EFFECT OF DIMERCAPTOSUCCINIC ACID PER-OS ON DISTRIBUTION AND EXCRETION OF PB-210 AND HG-203 IN MICE.ACTA PHARMACOLOGICA SINICA,15(4),379-382. |
| MLA | LIANG, YY,et al."EFFECT OF DIMERCAPTOSUCCINIC ACID PER-OS ON DISTRIBUTION AND EXCRETION OF PB-210 AND HG-203 IN MICE".ACTA PHARMACOLOGICA SINICA 15.4(1994):379-382. |
入库方式： OAI收割
来源：上海药物研究所
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