ANALGESIC EFFECT AND TOXICITY OF 3,15-DIACETYL-BENZOYLACONINE AND COMPARISON WITH ITS ANALOGS
文献类型：期刊论文
| 作者 | ZHENG, P; YANG, YR; ZHANG, WP; WANG, HC; LAO, AN |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1994-05 |
| 卷号 | 15期号:3页码:239-243 |
| 关键词 | ACONITE ACONITINE ANALGESIA ARRHYTHMIA RESPIRATION |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | 3, 15-Diacetylbenzoylaconine (Dia) is a new aconite alkaloid derivative. The analgesic ED50(95 % confidence limit) of sc Dia measured with the HAc-induced writhing method, hot-plate method and electric stimulation method in mice were 2.76 (2.34-3.26), 3.50 (2.69-4.54), and 4. 20 (3.72-4.73) mg.kg-1, respectively. With the hot-plate method and tail flick method in rats, the analgesic ED50 of ip Dia were 2.75 (2.28-3.31) and 5.24 (4.35-6.31) mg.kg-1 respectively. The LD50 of sc Dia in mice and ip Dia in rats were 21.68 (17.25-27.25) and 10. 96 (8.24-14.56) mg.kg-1, respectively. The magnitude of the analgesic therapeutic indices of Dia, 3-acetylaconitine (Ace) and aconitine (Aco) in all the above-mentioned algo-model were in the order of Dia > Ace > Aco. When they were injected iv at 0.1 ml - min-1 in rats , the doses of Dia, Ace, and Aco producing arrythmia were 3. 3, 0. 8, and 0. 5 times as large as those producing analgesia while those of Dia, Ace, and Aco inducing respiratory inhibition were 3. 9, 0. 5 and 0. 3 times, respectively. The magnitudes of the oil/water distribution coefficients with two method and the quotient ED50 icv/ED50 sc of Dia and Ace were > Aco. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:255104 |
| WOS记录号 | WOS:A1994NL32300013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275100]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA 2.BAOTOU MED COLL,DEPT PHARMACOL,BAOTOU 014010,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | ZHENG, P,YANG, YR,ZHANG, WP,et al. ANALGESIC EFFECT AND TOXICITY OF 3,15-DIACETYL-BENZOYLACONINE AND COMPARISON WITH ITS ANALOGS[J]. ACTA PHARMACOLOGICA SINICA,1994,15(3):239-243. |
| APA | ZHENG, P,YANG, YR,ZHANG, WP,WANG, HC,&LAO, AN.(1994).ANALGESIC EFFECT AND TOXICITY OF 3,15-DIACETYL-BENZOYLACONINE AND COMPARISON WITH ITS ANALOGS.ACTA PHARMACOLOGICA SINICA,15(3),239-243. |
| MLA | ZHENG, P,et al."ANALGESIC EFFECT AND TOXICITY OF 3,15-DIACETYL-BENZOYLACONINE AND COMPARISON WITH ITS ANALOGS".ACTA PHARMACOLOGICA SINICA 15.3(1994):239-243. |
入库方式： OAI收割
来源：上海药物研究所
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