FACILITATION OF CHOLINERGIC TRANSMISSION BY HUPERZINE-A IN TOAD PARAVERTEBRAL GANGLIA IN-VITRO
文献类型：期刊论文
| 作者 | ZHANG, GB; WANG, MY; ZHENG, JQ; TANG, XC
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1994-03 |
| 卷号 | 15期号:2页码:158-161 |
| 关键词 | HUPERZINE A CHOLINESTERASE INHIBITORS ACETYLCHOLINE CARBACHOL SYMPATHETIC GANGLIA ELECTROPHYSIOLOGY |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Using the intracellular recording techniques of toad paravertebral ganglia (PVG), the effects of cholinesterase inhibitor huperzine A (Hup-A), and alkaloid first isolated from Huperzia serrata (Thunb) Trev in China, on the synaptic transmission were studied. In 30 PVG cells tested, no remarkable changes in membrane potential and input resistance were observed during superfusion of Hup-A 0.3 or 1 mu mol . L(-1) (n = 12, P < 0.05), and much faster, stronger, and longer in action at 50 or 100 mu mol . L(-1) (n = 11). The amplitude and duration of exogenous acetylcholine-, but not carbachol-, induced depolarization were increased (P<0.05). It is concluded that Hup-A is a selective and potent cholinesterase inhibitor, by which action it facilitates the cholinergic transmission of PVG neurons. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:255005 |
| WOS记录号 | WOS:A1994NA94100016 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275105]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA 2.WANNAN MED COLL,CELL ELECTROPHYSIOL LAB,WUHAN 241001,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | ZHANG, GB,WANG, MY,ZHENG, JQ,et al. FACILITATION OF CHOLINERGIC TRANSMISSION BY HUPERZINE-A IN TOAD PARAVERTEBRAL GANGLIA IN-VITRO[J]. ACTA PHARMACOLOGICA SINICA,1994,15(2):158-161. |
| APA | ZHANG, GB,WANG, MY,ZHENG, JQ,&TANG, XC.(1994).FACILITATION OF CHOLINERGIC TRANSMISSION BY HUPERZINE-A IN TOAD PARAVERTEBRAL GANGLIA IN-VITRO.ACTA PHARMACOLOGICA SINICA,15(2),158-161. |
| MLA | ZHANG, GB,et al."FACILITATION OF CHOLINERGIC TRANSMISSION BY HUPERZINE-A IN TOAD PARAVERTEBRAL GANGLIA IN-VITRO".ACTA PHARMACOLOGICA SINICA 15.2(1994):158-161. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。