SITES OF ANALGESIC ACTION OF 3,15-DIACETYLBENZOYLACONINE
文献类型：期刊论文
| 作者 | ZHANG, HL; YANG, YR; WANG, Y; ZHENG, P; WANG, HC; LAO, AN |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1994-03 |
| 卷号 | 15期号:2页码:176-180 |
| 关键词 | ACONITINE ANALGESIA SPINAL CORD PERIAQUEDUCTAL GRAY LOCUS COERULEUS |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | In the rat hot plate test, vocalization induced by electric stimulation, tail flick test, and the mouse acetic acid writhing test, 3, 15-diacetylhenzoylaconine (DABA) ip exhibited a dose-dependent analgesic activity. Intrathecally (ith) administered DABA (527, 1186 mu g kg(-1)) had no analgesic action. croinjection of DABA 35 - 75 mu g kg(-1) mu g, into the cerebral ventricle (icv) or the periaqueductal gray (FAG) exerted a remarkable analgesic activity, which was abolished after bilateral lesions of locus coeruleus (LC). Microinjection of DABA (20 mu g) into LC failed to produce apparent analgesic action. These results suggested that the sites of analgesia of DABA were mainly at the central supraspinal structures, and FAG was one of the primary sites, while LC was one of the intermediate links. |
| WOS关键词 | MESACONITINE ; MECHANISM ; NUCLEUS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:255103 |
| WOS记录号 | WOS:A1994NA94100021 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275106]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | ZHANG, HL |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | ZHANG, HL,YANG, YR,WANG, Y,et al. SITES OF ANALGESIC ACTION OF 3,15-DIACETYLBENZOYLACONINE[J]. ACTA PHARMACOLOGICA SINICA,1994,15(2):176-180. |
| APA | ZHANG, HL,YANG, YR,WANG, Y,ZHENG, P,WANG, HC,&LAO, AN.(1994).SITES OF ANALGESIC ACTION OF 3,15-DIACETYLBENZOYLACONINE.ACTA PHARMACOLOGICA SINICA,15(2),176-180. |
| MLA | ZHANG, HL,et al."SITES OF ANALGESIC ACTION OF 3,15-DIACETYLBENZOYLACONINE".ACTA PHARMACOLOGICA SINICA 15.2(1994):176-180. |
入库方式： OAI收割
来源：上海药物研究所
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