ANTITUMOR EFFECT OF ALPHA-ISOMER OF ANORDRIN IN-VITRO AND CELL-CYCLE ARREST AT G(1) PHASE
文献类型：期刊论文
| 作者 | WENG, SM; XU, YP; XU, B
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1994-01 |
| 卷号 | 15期号:1页码:47-50 |
| 关键词 | NORANDROSTANES ANORDRIN EXPERIMENTAL LIVER NEOPLASMS LEUKEMIA-P388 THYMIDINE URIDINE CELL CYCLE |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Alpha isomer of anordrin (2alpha, 17alpha-diethyl-A-norandrostane-2beta, 17beta-diol dipropionate, alpha-Ano) inhibited mouse hepatoma (Hep A) and P388 cell growth in vitro. Alpha-Ano (20 mug.ml-1) inhibited the incorporation of [H-3]uridine and [H-3]thymidine into RNA and DNA within 3 h, but the inhibition of L-[H-3]lysine incoporating into protein was not obvious. Alpha-Ano had no effect on the DNA-dependent RNA synthsis with purified nuclei of Hep A cells. It is suggested that the inhibition of RNA and DNA syntheses is the major cause of the cytostatic effect. Alpha-Ano blocked the P388 cells at G1/G0 phase, and the delay in G1/G0 to S phase transition plays an important role in the inhibition of P388 cell growth. |
| WOS关键词 | DNA |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:255089 |
| WOS记录号 | WOS:A1994MR12100008 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275109]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | WENG, SM |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | WENG, SM,XU, YP,XU, B. ANTITUMOR EFFECT OF ALPHA-ISOMER OF ANORDRIN IN-VITRO AND CELL-CYCLE ARREST AT G(1) PHASE[J]. ACTA PHARMACOLOGICA SINICA,1994,15(1):47-50. |
| APA | WENG, SM,XU, YP,&XU, B.(1994).ANTITUMOR EFFECT OF ALPHA-ISOMER OF ANORDRIN IN-VITRO AND CELL-CYCLE ARREST AT G(1) PHASE.ACTA PHARMACOLOGICA SINICA,15(1),47-50. |
| MLA | WENG, SM,et al."ANTITUMOR EFFECT OF ALPHA-ISOMER OF ANORDRIN IN-VITRO AND CELL-CYCLE ARREST AT G(1) PHASE".ACTA PHARMACOLOGICA SINICA 15.1(1994):47-50. |
入库方式： OAI收割
来源：上海药物研究所
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