CHARACTERIZATION AND DISTRIBUTION OF MU-OPIOID RECEPTORS IN RABBIT CEREBELLUM
文献类型：期刊论文
| 作者 | LU, YF; LI, GF; CHI, ZQ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1993-11 |
| 卷号 | 14期号:6页码:489-491 |
| 关键词 | OHMEFENTANYL ETORPHINE ENKEPHALINS ENDORPHIN RECEPTORS CEREBELLUM RADIOLIGAND ASSAY AUTORADIOGRAPHY |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | The binding characteristics and distributions of [H-3]ohmefentanyl ([H-3]OMF), [H-3]etorphine, [H-3]N-methyl-N-[7-(I-pyrrolidinyl)-1-oxa-spiro(4,5)dec-8-yl] benzeneacetamide [H-3]U-69593), and [H-3] (D-penicillamine2, D-penicillamine5) enkephalin ([H-3]DPDPE) in rabbit cerebellum were studied. In saturation experiment, [H-3]OMF bound to a single population of sites with K(d) = 2.2 +/- 1.3 nmol . L-1 and B(max) = 69 +/- 13 fmol/mg protein. The results of [H-3]etorphine (K(d) = 1.0 +/- 0. 4 nmol . L-1 and B(max) = 16 +/- 6 fmol/mg protein) were similar to those of [H-3]OMF. There were no specific bindings of [H-3]U-69593 and [H-3]DPDPE in rabbit cerebellar membranes. In autoradiographic study, the gray scales of specific binding for [H-3] OMF , [H-3] etorphine , [H-3]U-69593, and [H-3]DPDPE were 20.2 +/- 4.6, 8.5 +/- 2. 7, 2. 0 +/- 0. 7, and 3. 2 +/- 4. 3, respectively. The gray matter of rabbit cerebellum was intensely labeled by [H-3]OMF and [H-3]etorphine, but not by [H-3]U-69593 or [H-3]DPDPE. These results suggested that the rabbit cerebellum contained mu opioid receptors. |
| WOS关键词 | OPIATE BINDING-SITES ; OHMEFENTANYL ; SUBTYPE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:222670 |
| WOS记录号 | WOS:A1993MG89800003 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275116]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | LU, YF |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI JOINT LAB LIFE SCI,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | LU, YF,LI, GF,CHI, ZQ. CHARACTERIZATION AND DISTRIBUTION OF MU-OPIOID RECEPTORS IN RABBIT CEREBELLUM[J]. ACTA PHARMACOLOGICA SINICA,1993,14(6):489-491. |
| APA | LU, YF,LI, GF,&CHI, ZQ.(1993).CHARACTERIZATION AND DISTRIBUTION OF MU-OPIOID RECEPTORS IN RABBIT CEREBELLUM.ACTA PHARMACOLOGICA SINICA,14(6),489-491. |
| MLA | LU, YF,et al."CHARACTERIZATION AND DISTRIBUTION OF MU-OPIOID RECEPTORS IN RABBIT CEREBELLUM".ACTA PHARMACOLOGICA SINICA 14.6(1993):489-491. |
入库方式： OAI收割
来源：上海药物研究所
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