ANTITUMOR-ACTIVITY AND IMMUNO-POTENTIATING ACTIONS OF ACHYRANTHES-BIDENTATA POLYSACCHARIDES
文献类型：期刊论文
| 作者 | XIANG, DB; LI, XY |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1993-11 |
| 卷号 | 14期号:6页码:556-561 |
| 关键词 | ACHYRANTHES-BIDENTATA POLYSACCHARIDES ANTIBODY-PRODUCING CELLS IGG LYMPHOCYTE TRANSFORMATION NATURAL KILLER CELLS TUMOR NECROSIS FACTOR |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | Achyranthes bidentata polysaccharides (ABP), isolated from the root of Achyranthes bidentata Blume, 50 mg . kg-1 ip or 250 mg . kg-1 ig to ICR mice inhibited the growth of sarcoma 180. ABP 50 and 100 mg . kg-1 ip prolongated the survival days of mice bearing Ehrlich carcinoma. ABP 50-800 mug . ml-1 did not exert direct cytotoxic effect in vitro on S180 cells, but enhanced the cytotoxicity of peritoneal macrophages against S180 cells. ABP 50 mg . kg-1 ip X 17 d or 250 mg . kg-1 ig X 16 d, promoted the plaque forming cells (PFC) response to sheep red blood cells (SRBC) and serum IgG level as well as splenocyte proliferation induced by mitogen Con A or LPS in tumor-induced immunodeficient mice. ABP also elevated the NK cell activity and serum TNF content in mice bearing S180. These results indicated that the antitumor effect of ABP may be related to its potentiating effect on both specific and nonspecific host immunological responses. |
| WOS关键词 | CELL |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1993MG89800021 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275118]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | XIANG, DB |
| 作者单位 | CHINESE ACAD SCI, SHANGHAI INST MAT MED, SHANGHAI 200031, PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | XIANG, DB,LI, XY. ANTITUMOR-ACTIVITY AND IMMUNO-POTENTIATING ACTIONS OF ACHYRANTHES-BIDENTATA POLYSACCHARIDES[J]. ACTA PHARMACOLOGICA SINICA,1993,14(6):556-561. |
| APA | XIANG, DB,&LI, XY.(1993).ANTITUMOR-ACTIVITY AND IMMUNO-POTENTIATING ACTIONS OF ACHYRANTHES-BIDENTATA POLYSACCHARIDES.ACTA PHARMACOLOGICA SINICA,14(6),556-561. |
| MLA | XIANG, DB,et al."ANTITUMOR-ACTIVITY AND IMMUNO-POTENTIATING ACTIONS OF ACHYRANTHES-BIDENTATA POLYSACCHARIDES".ACTA PHARMACOLOGICA SINICA 14.6(1993):556-561. |
入库方式： OAI收割
来源：上海药物研究所
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