EFFECT OF TARGETING TREATMENT OF MITOMYCIN-C IMMUNOCONJUGATE ON STOMACH NEOPLASM
文献类型：期刊论文
| 作者 | CHEN, LJ; ZHANG, SY; ZHANG, JL; ZHANG, Z; LI, S; CHEN, M; ZHANG, XY; CHEN, XT |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1993-11 |
| 卷号 | 14期号:6页码:572-576 |
| 关键词 | MONOCLONAL ANTIBODIES MITOMYCIN-C IMMUNOLOGICAL CYTOTOXICITY STOMACH NEOPLASMS RECOMBINANT INTERFERON ALFA NEOPLASM ANTIGENS NUDE MICE SUBRENAL CAPSULE ASSAY |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | An anti-gastric cancer monoclonal antibody MGb2-mitomycin C conjugate via dextran T-70 as intermediate (MGb2-PAD-MMC) was produced, and 28 - 30 g molecules of MMC were introduced into 1 g molecule of MGb2. Ninety-six hours after ip of I-125-MGb2-PAD-MMC (1.48 MBq/22 mug MGb2 per mouse) to nude mice bearing human gastric cancer SGC-7901, the tumor tissue:blood (T/NT) radioactivity ratio was 2.6, very much higher than that of the control I-125-normal IgG-PAD-MMC group (T /NT = 0. 20). Single photo computed tomography imaging confirmed the results of biodistribution study. MGb2-PAD-MMC exhibited selective killing action on the SGC7901 cells in vitro, which was considered to be mediated by monoclonal antibody MGb2. Nude mice inoculated with SGC-7901 xenograft in bilateral subrenal capsule were treated by MMC (ip), human recombinant interferon-alpha (Hu-IFN-alpha im), MGb2-PAD-MMC (ip) and MGb2-PAD-MMC + Hu-IFN-alpha daily for 5 d beginning 4 h after inoculation. The efficacy of the reagents estimated by the reduction of tumor size and calculated by T/C (%), was 28.3%, 16.4%, 47.8%, and 83.l%, respectively. These results demonstrated that the antitumor effect of MGb2-PAD-MMC was superior to free MMC, and that the Hu-IFN-alpha might further enhance the action of MGb2-PAD-MMC. |
| WOS关键词 | MONOCLONAL-ANTIBODY ; GASTRIC-CANCER |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:222571 |
| WOS记录号 | WOS:A1993MG89800025 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275119]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | CHEN, LJ |
| 作者单位 | FOURTH MIL MED UNIV,XIJING HOSP,GASTROENTEROL LAB,XIAN 710032,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | CHEN, LJ,ZHANG, SY,ZHANG, JL,et al. EFFECT OF TARGETING TREATMENT OF MITOMYCIN-C IMMUNOCONJUGATE ON STOMACH NEOPLASM[J]. ACTA PHARMACOLOGICA SINICA,1993,14(6):572-576. |
| APA | CHEN, LJ.,ZHANG, SY.,ZHANG, JL.,ZHANG, Z.,LI, S.,...&CHEN, XT.(1993).EFFECT OF TARGETING TREATMENT OF MITOMYCIN-C IMMUNOCONJUGATE ON STOMACH NEOPLASM.ACTA PHARMACOLOGICA SINICA,14(6),572-576. |
| MLA | CHEN, LJ,et al."EFFECT OF TARGETING TREATMENT OF MITOMYCIN-C IMMUNOCONJUGATE ON STOMACH NEOPLASM".ACTA PHARMACOLOGICA SINICA 14.6(1993):572-576. |
入库方式： OAI收割
来源：上海药物研究所
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