COMPARATIVE-STUDY ON THE EFFICACY, ACCEPTABILITY, AND SIDE-EFFECTS OF A CONTRACEPTIVE PILL ADMINISTERED BY THE ORAL AND THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL
文献类型：期刊论文
| 作者 | COUTINHO, EM; MASCARENHAS, I; DEACOSTA, OM; FLORES, JG; GU, ZP; LADIPO, OA; ADEKUNLE, AO; OTOLORIN, EO; SHAABAN, MM; OYOON, MA |
| 刊名 | CLINICAL PHARMACOLOGY & THERAPEUTICS
 |
| 出版日期 | 1993-11 |
| 卷号 | 54期号:5页码:540-545 |
| ISSN号 | 0009-9236 |
| DOI | 10.1038/clpt.1993.186 |
| 文献子类 | Article |
| 英文摘要 | The objective of this multicenter randomized clinical trial was to compare the efficacy, acceptability, and occurrence of side effects associated with the oral versus vaginal route of administration of contraceptive pills. Eight hundred nineteen healthy, parous women of reproductive age were recruited at family planning clinics and research centers, members of the South to South Cooperation in Reproductive Health, in seven countries of the developing world. These women were randomly assigned to use either oral or vaginal administration of the same contraceptive pill, which contained 250 mug levonorgestrel and 50 mug ethinyl estradiol. No statistically significant differences were found in discontinuation rates between the two groups after 1 year. Involuntary pregnancy rates after 1 year were not statistically significantly different between the two groups. The vaginal route of administration appears to be as acceptable and efficacious as the oral route. |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1993MU53000009 |
| 出版者 | MOSBY-YEAR BOOK INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275122]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | COUTINHO, EM |
| 作者单位 | 1.UNIV ASSIUT,DEPT OBSTET & GYNECOL,ASSIUT,EGYPT 2.INST NACL ENDOCRINOL,HAVANA,CUBA 3.INST NACL NUTR SALVADOR ZUBIRAN,DEPT REPROD BIOL,MEXICO CITY 14000,DF,MEXICO 4.SHANGHAI INST MATERIA MED,SHANGHAI,PEOPLES R CHINA 5.UNIV IBADAN,DEPT OBSTET & GYNECOL,IBADAN,NIGERIA 6.POPULAT COUNCIL,CTR BIOMED RES,NEW YORK,NY 10021 7.MENIA UNIV,DEPT OBSTET & GYNECOL,MENIA,EGYPT 8.UNIV ZAMBIA,LUSAKA,ZAMBIA |
| 推荐引用方式 GB/T 7714 | COUTINHO, EM,MASCARENHAS, I,DEACOSTA, OM,et al. COMPARATIVE-STUDY ON THE EFFICACY, ACCEPTABILITY, AND SIDE-EFFECTS OF A CONTRACEPTIVE PILL ADMINISTERED BY THE ORAL AND THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS,1993,54(5):540-545. |
| APA | COUTINHO, EM.,MASCARENHAS, I.,DEACOSTA, OM.,FLORES, JG.,GU, ZP.,...&SEGAL, SJ.(1993).COMPARATIVE-STUDY ON THE EFFICACY, ACCEPTABILITY, AND SIDE-EFFECTS OF A CONTRACEPTIVE PILL ADMINISTERED BY THE ORAL AND THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL.CLINICAL PHARMACOLOGY & THERAPEUTICS,54(5),540-545. |
| MLA | COUTINHO, EM,et al."COMPARATIVE-STUDY ON THE EFFICACY, ACCEPTABILITY, AND SIDE-EFFECTS OF A CONTRACEPTIVE PILL ADMINISTERED BY THE ORAL AND THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL".CLINICAL PHARMACOLOGY & THERAPEUTICS 54.5(1993):540-545. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。