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POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN ARGININE-INDUCED ANALGESIA

文献类型：期刊论文

作者JI, XQ; ZHU, XZ
刊名ACTA PHARMACOLOGICA SINICA
出版日期1993-07
卷号14期号:4页码:289-291
关键词ARGININE NITROPRUSSIDE NITRIC OXIDE GUANOSINE CYCLIC MONOPHOSPHATE NALOXONE ANALGESIA
ISSN号0253-9756
文献子类Article
英文摘要Intracerebroventricular injection (icv) of 1-arginine (Arg, 0.5, 5.0, 50 mug) produced a dose-dependent prolongation in the hot-plate latency in mice. A similar result was obtained when nitroprusside (0.1, 1.0, 10 mug, icv) was given. Naloxone (2 mg . kg-1, ip) failed to antagonize the effects of Arg or nitroprusside. But Arg-induced antinociception was attenuated by N(G)-monomethyl-arginine (NMMA, 10 mug). 8-Bromoguanosine 3' : 5' cyclic monophosphate (bromo-cGMP, 50 mug) also produced an antinoceptive effect. The results suggest that Arg induces an analgesia possibly via activation of nitric oxide-cGMP pathway.
WOS关键词BRAIN
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:A1993LM10200001
出版者ACTA PHARMACOLOGICA SINICA
源URL[http://119.78.100.183/handle/2S10ELR8/275126]  
专题中国科学院上海药物研究所
通讯作者JI, XQ
作者单位CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA.
推荐引用方式
GB/T 7714		 JI, XQ,ZHU, XZ. POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN ARGININE-INDUCED ANALGESIA[J]. ACTA PHARMACOLOGICA SINICA,1993,14(4):289-291.
APA JI, XQ,&ZHU, XZ.(1993).POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN ARGININE-INDUCED ANALGESIA.ACTA PHARMACOLOGICA SINICA,14(4),289-291.
MLA JI, XQ,et al."POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN ARGININE-INDUCED ANALGESIA".ACTA PHARMACOLOGICA SINICA 14.4(1993):289-291.

入库方式： OAI收割

来源：上海药物研究所

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