EFFECTS OF ACHYRANTHES-BIDENTATA POLYSACCHARIDES ON INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA PRODUCTION FROM MOUSE PERITONEAL-MACROPHAGES
文献类型：期刊论文
| 作者 | XIANG, DB; LI, XY |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1993-07 |
| 卷号 | 14期号:4页码:332-336 |
| 关键词 | ACHYRANTHES-BIDENTATA POLYSACCHARIDES MACROPHAGES INTERLEUKIN-1 TUMOR NECROSIS FACTOR LIPOPOLYSACCHARIDES |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Achyranthes bidentata polysaccharides (ABP), extracted from the root of Achyranthes bidentata, induced interleukin-1 (IL-1) synthesis as well as tumor necrosis factor-alpha (TNF-alpha) synthesis and secretion from thioglycolate-primed mouse peritoneal macrophages in vitro. ABP 100-800 mug.ml-1 enhanced both synthesis and release of IL-1 when stimulated by lipopolysaccharides (LPS) (5 mug.ml-1), but had no significant influences on synthesis and release of TNF-alpha induced by LPS (10 mug.ml-1). Studies on IL-1 and TNF-alpha production induced by ABP (200 mug.ml-1) alone or plus LPS showed that peak levels of IL-1 release reached at 24 h and that of TNF-alpha release at about 2-6 h after incubation. Peritoneal macrophages from mice ip ABP 25 and 50 mg.kg-1 .d-1 X 5 d produced much more IL-1 than those from control group. Peritoneal macrophages from ip ABP 100 mg.kg-1.d-1 X 6 d alone released more TNF-alpha vs control group, and showed a synergetic action with LPS (10 mug.ml-1), which was as strong as the positive control agent BCG. These results provide an explanation for the immunopotentiating effect of ABP. |
| WOS关键词 | GLUCAN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:222657 |
| WOS记录号 | WOS:A1993LM10200013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275127]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | XIANG, DB |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | XIANG, DB,LI, XY. EFFECTS OF ACHYRANTHES-BIDENTATA POLYSACCHARIDES ON INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA PRODUCTION FROM MOUSE PERITONEAL-MACROPHAGES[J]. ACTA PHARMACOLOGICA SINICA,1993,14(4):332-336. |
| APA | XIANG, DB,&LI, XY.(1993).EFFECTS OF ACHYRANTHES-BIDENTATA POLYSACCHARIDES ON INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA PRODUCTION FROM MOUSE PERITONEAL-MACROPHAGES.ACTA PHARMACOLOGICA SINICA,14(4),332-336. |
| MLA | XIANG, DB,et al."EFFECTS OF ACHYRANTHES-BIDENTATA POLYSACCHARIDES ON INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA PRODUCTION FROM MOUSE PERITONEAL-MACROPHAGES".ACTA PHARMACOLOGICA SINICA 14.4(1993):332-336. |
入库方式： OAI收割
来源：上海药物研究所
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