EFFECTS OF (-)-STEPHOLIDINE AND TETRAHYDROBERBERINE ON HIGH POTASSIUM-EVOKED CONTRACTION AND CALCIUM INFLUX IN RAT ARTERY
文献类型：期刊论文
| 作者 | YANG, S; MIAO, YS; HAN, Q; JIANG, MH; JIN, GZ
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1993-05 |
| 卷号 | 14期号:3页码:235-237 |
| 关键词 | STEPHOLIDINE TETRAHYDROBERBERINE VERAPAMIL CALCIUM RADIOISOTOPES THORACIC AORTA CALCIUM CHANNEL BLOCKERS |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | The relaxant effects of (-)-stepholidine ((-)-SPD) and tetrahydroberberine (THB) on rat aorta were studied in vitro . (-)-SPD IC50 18. 1 (95% confidence limits 11.1-29.5) mumol . L-1 and THB IC50 18. 6 (95 % confidence limits 9. 2 - 37.9) mumol . L-1 inhibited the contractions caused by KCl (100 mmol . L-1) concentration-dependently. Both (-)-SPD and THB markedly inhibited the 160 mmol . L-1 KCl-stimulated Ca-45 influx. The inhibitions by (-)-SPD 10 mumol . L-1 and 100 mumol . L-1 were 18 +/- 13% (P > 0.05) and 47.0 +/- 2.8% (P < 0.01), respectively. The inhibitions by THB 10 mumol . L-1 and 100 mumol . L-1 were 36 +/- 9% (P < 0.01) and 43 +/- 8 % (P < 0.05), respectively. The results showed that the effective concentrations of the 2 drugs inhibiting high KCl-induced contraction and Ca-45 transmembrane influx in rat thoracic aorta were at a similar level, and that they were nearly 1/100 and 1/10 of those of verapamil respectively, indicating that (-)-SPD and THB had similar calcium channel blocking effect on rat artery, but were weaker than verapamil. |
| WOS关键词 | AORTA |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:222603 |
| WOS记录号 | WOS:A1993LC29800013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275134]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | YANG, S |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MATERIA MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | YANG, S,MIAO, YS,HAN, Q,et al. EFFECTS OF (-)-STEPHOLIDINE AND TETRAHYDROBERBERINE ON HIGH POTASSIUM-EVOKED CONTRACTION AND CALCIUM INFLUX IN RAT ARTERY[J]. ACTA PHARMACOLOGICA SINICA,1993,14(3):235-237. |
| APA | YANG, S,MIAO, YS,HAN, Q,JIANG, MH,&JIN, GZ.(1993).EFFECTS OF (-)-STEPHOLIDINE AND TETRAHYDROBERBERINE ON HIGH POTASSIUM-EVOKED CONTRACTION AND CALCIUM INFLUX IN RAT ARTERY.ACTA PHARMACOLOGICA SINICA,14(3),235-237. |
| MLA | YANG, S,et al."EFFECTS OF (-)-STEPHOLIDINE AND TETRAHYDROBERBERINE ON HIGH POTASSIUM-EVOKED CONTRACTION AND CALCIUM INFLUX IN RAT ARTERY".ACTA PHARMACOLOGICA SINICA 14.3(1993):235-237. |
入库方式： OAI收割
来源：上海药物研究所
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