DISTRIBUTION OF C-14-LABELED AT DIOXOPIPERAZINE OR METHYL MORPHOLINE GROUP OF PROBIMANE BY WHOLE-BODY AUTORADIOGRAPHY
文献类型：期刊论文
| 作者 | LU, DY; XU, B ; ZHANG, X; CHEN, RT
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1993-03 |
| 卷号 | 14期号:2页码:171-173 |
| 关键词 | LUNG NEOPLASMS PROBIMANE ANTINEOPLASTIC AGENTS AUTORADIOGRAPHY CARBON RADIOISOTOPES TISSUE DISTRIBUTION PHARMACOKINETICS |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Probimane (AT-2153) is a new anticancer compound. It was first developed in this Institute. It is effective against mouse tumors S37, S180, Lewis lung carcinoma, L1210 and human pulmonary adenocarcinoma heterotransplanted into nude mice. In the present work, C-14 was labeled at central dioxopiperazine or methyl morpholine group of probimane 120 mg. kg-1 was injected iv in mice bearing Lewis lung carcinoma by whole body autoradiography. The results showed that probimane was broken into at least two parts: a central part and a methyl morpholine group. The central part of compound hardly penetrated through the blood-brain barrier, but accumulated in the urinary bladder. The methyl morpholine group showed a high affinity to tumor tissue and accumulated in spleen, bone and liver. |
| WOS关键词 | ICRF-159 |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:222560 |
| WOS记录号 | WOS:A1993KQ86600022 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275135]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | LU, DY |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | LU, DY,XU, B,ZHANG, X,et al. DISTRIBUTION OF C-14-LABELED AT DIOXOPIPERAZINE OR METHYL MORPHOLINE GROUP OF PROBIMANE BY WHOLE-BODY AUTORADIOGRAPHY[J]. ACTA PHARMACOLOGICA SINICA,1993,14(2):171-173. |
| APA | LU, DY,XU, B,ZHANG, X,&CHEN, RT.(1993).DISTRIBUTION OF C-14-LABELED AT DIOXOPIPERAZINE OR METHYL MORPHOLINE GROUP OF PROBIMANE BY WHOLE-BODY AUTORADIOGRAPHY.ACTA PHARMACOLOGICA SINICA,14(2),171-173. |
| MLA | LU, DY,et al."DISTRIBUTION OF C-14-LABELED AT DIOXOPIPERAZINE OR METHYL MORPHOLINE GROUP OF PROBIMANE BY WHOLE-BODY AUTORADIOGRAPHY".ACTA PHARMACOLOGICA SINICA 14.2(1993):171-173. |
入库方式： OAI收割
来源：上海药物研究所
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