NATURAL AND SYNTHETIC HUPERZINE-A - EFFECT ON CHOLINERGIC FUNCTION IN-VITRO AND IN-VIVO
文献类型：期刊论文
| 作者 | HANIN, I; TANG, XC ; KINDEL, GL; KOZIKOWSKI, AP
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| 刊名 | ALZHEIMERS DISEASE: AMYLOID PRECUSOR PROTEINS, SIGNAL TRANSDUCTION, AND NEURONAL TRANSPLANTATION
 |
| 出版日期 | 1993 |
| 卷号 | 695页码:304-306 |
| ISSN号 | 0077-8923 |
| DOI | 10.1111/j.1749-6632.1993.tb23071.x |
| 文献子类 | Article; Proceedings Paper |
| 英文摘要 | Huperzine A has been shown to be useful in the treatment of symptoms of dementia of the Alzheimer type. Our initial attempts to synthesize (-)Huperzine A resulted in the racemic mixture of (+/-)Huperzine A. We have therefore compared the in vitro and in vivo effects of(+/-)Huperzine A with those of(-)Huperzine A in rats. The results indicate a similar biological mechanism of action between the two, but that the racemic mixture of (c)Huperzine A has a weaker biological activity than the natural product (+/-)Huperzine A, presumably due to the presence in the mixture of(+)Huperzine A,which is considerably less potent than the (-)isomer. |
| 资助项目 | NIA NIH HHS[NIA AG07591] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Science & Technology - Other Topics ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:A1993BZ92T00054 |
| 出版者 | NEW YORK ACAD SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275140]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | HANIN, I |
| 作者单位 | 1.MAYO CLIN,DEPT CHEM RES,JACKSONVILLE,FL 32224 2.ACAD SINICA,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | HANIN, I,TANG, XC,KINDEL, GL,et al. NATURAL AND SYNTHETIC HUPERZINE-A - EFFECT ON CHOLINERGIC FUNCTION IN-VITRO AND IN-VIVO[J]. ALZHEIMERS DISEASE: AMYLOID PRECUSOR PROTEINS, SIGNAL TRANSDUCTION, AND NEURONAL TRANSPLANTATION,1993,695:304-306. |
| APA | HANIN, I,TANG, XC,KINDEL, GL,&KOZIKOWSKI, AP.(1993).NATURAL AND SYNTHETIC HUPERZINE-A - EFFECT ON CHOLINERGIC FUNCTION IN-VITRO AND IN-VIVO.ALZHEIMERS DISEASE: AMYLOID PRECUSOR PROTEINS, SIGNAL TRANSDUCTION, AND NEURONAL TRANSPLANTATION,695,304-306. |
| MLA | HANIN, I,et al."NATURAL AND SYNTHETIC HUPERZINE-A - EFFECT ON CHOLINERGIC FUNCTION IN-VITRO AND IN-VIVO".ALZHEIMERS DISEASE: AMYLOID PRECUSOR PROTEINS, SIGNAL TRANSDUCTION, AND NEURONAL TRANSPLANTATION 695(1993):304-306. |
入库方式： OAI收割
来源：上海药物研究所
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