COMPARATIVE-STUDY ON THE EFFICACY AND ACCEPTABILITY OF 2 CONTRACEPTIVE PILLS ADMINISTERED BY THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL
文献类型：期刊论文
| 作者 | COUTINHO, EM; DESOUZA, JC; DASILVA, AR; DEACOSTA, OM; ALVAREZ, F; BRACHE, V; FLORES, JG; VASQUEZESTRADA, L; SANTO, R; BASSOL, S |
| 刊名 | CLINICAL PHARMACOLOGY & THERAPEUTICS
 |
| 出版日期 | 1993-01 |
| 卷号 | 53期号:1页码:65-75 |
| ISSN号 | 0009-9236 |
| DOI | 10.1038/clpt.1993.10 |
| 文献子类 | Article |
| 英文摘要 | The efficacy and acceptability of two widely used oral contraceptive tablets, one containing 250 mg levonorgestrel and 50 mug ethinyl estradiol and the other containing 150 mug desogestrel and 30 mug ethinyl estradiol, administered by the vaginal route were compared in 1055 women studied over 12,630 woman-months of vaginal contraceptive pill use. This multicenter clinical trial was performed in nine countries of the developing world by the ''South to South Cooperation in Reproductive Health,'' an organization founded by scientists from the Third World working in the area of reproductive health, and the study was developed and coordinated by one of these centers. The findings of this study confirm the efficacy of both these tablets when administered by the vaginal route. Involuntary pregnancy rates at 1 year of 2.78 for subjects in the levonorgestrel group and 4.54 for subjects the desogestrel group showed no statistically significant difference between the two groups. However, total discontinuation rates of 47.01 for subjects in the levonorgestrel group and 56.33 for subjects in the desogestrel group showed a statistically significant difference between the two groups, and discontinuation rates attributable able to prolonged bleeding of 0.6 for subjects in the levonorgestrel group and 3.2 for subjects in the desogestrel group were also significantly higher in the group of subjects using the desogestrel vaginal contraceptive pill. Blood pressure remained at admission values throughout treatment. A statistically significant weight increase from admission values occurred in both groups of subjects. |
| WOS关键词 | MULTI-CENTER ; ESTRADIOL ; RINGS ; NORGESTREL |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1993KK06600010 |
| 出版者 | MOSBY-YEAR BOOK INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275142]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | COUTINHO, EM |
| 作者单位 | 1.SHANGHAI INST MAT MED,SHANGHAI,PEOPLES R CHINA 2.CINSERHA PROFAMILIA,SANTO DOMINGO,DOMINICAN REP 3.ROCKEFELLER FDN,NEW YORK,NY 10036 4.UNIV ASSIUT,DEPT OBSTET & GYNECOL,ASSIUT,EGYPT 5.UNIV ZAMBIA,DEPT OBSTET & GYNECOL,LUSAKA,ZAMBIA 6.INST NACL NUTR SALVADOR ZUBIRAN,DEPT REPROD BIOL,MEXICO CITY 14000,DF,MEXICO 7.INST NACL ENDOCRINOL,HAVANA,CUBA 8.UNIV NAIROBI,DEPT OBSTET & GYNECOL,NAIROBI,KENYA 9.UNIV IBADAN,DEPT OBSTET & GYNECOL,IBADAN,NIGERIA |
| 推荐引用方式 GB/T 7714 | COUTINHO, EM,DESOUZA, JC,DASILVA, AR,et al. COMPARATIVE-STUDY ON THE EFFICACY AND ACCEPTABILITY OF 2 CONTRACEPTIVE PILLS ADMINISTERED BY THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS,1993,53(1):65-75. |
| APA | COUTINHO, EM.,DESOUZA, JC.,DASILVA, AR.,DEACOSTA, OM.,ALVAREZ, F.,...&SEGAL, SJ.(1993).COMPARATIVE-STUDY ON THE EFFICACY AND ACCEPTABILITY OF 2 CONTRACEPTIVE PILLS ADMINISTERED BY THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL.CLINICAL PHARMACOLOGY & THERAPEUTICS,53(1),65-75. |
| MLA | COUTINHO, EM,et al."COMPARATIVE-STUDY ON THE EFFICACY AND ACCEPTABILITY OF 2 CONTRACEPTIVE PILLS ADMINISTERED BY THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL".CLINICAL PHARMACOLOGY & THERAPEUTICS 53.1(1993):65-75. |
入库方式： OAI收割
来源：上海药物研究所
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