ANTITUMOR ACTIVITIES OF 4 DERIVATIVES OF ARTEMISIC ACID AND ARTEMISININ-B INVITRO
文献类型：期刊论文
| 作者 | SUN, WC; HAN, JX; YANG, WY; DENG, DA; YUE, XF |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1992-11 |
| 卷号 | 13期号:6页码:541-543 |
| 关键词 | ANTITUMOR DRUG SCREENING ASSAYS COLONY FORMING UNITS ASSAY ARTEMISININ DERIVATIVES CULTURED TUMOR CELLS TRYPAN BLUE |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | The cytotoxicities of 2 derivatives of artemisinin B and2 derivatives of artemisic acid (designated as Compound A, B, C. and D) were investigated, using trypan blue dye exclusion test and colony-forming units assay. At the concentration of 5 mug . ml-1, the inhibition rates of these 4 compounds against murine leukemia cell line P388 were > 85%. When tested against human hepatoma cell line SMMC-7721 at 25 mug . ml-1, the inhibition rates of Compound A, B, C, and D were found to be 92.3%, 96.9%, 84%, and 82.1%, respectively, and 27%, 8%, 37.8%, 1.7% against normal human embryonic lung cell line WI-38, respectively. These 4 compounds all showed an inhibition rate of 100% against human gastric cancer cell line SGC-7901 at 50 mug . ml-1. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| WOS记录号 | WOS:A1992JX79000017 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275146]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | SUN, WC |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | SUN, WC,HAN, JX,YANG, WY,et al. ANTITUMOR ACTIVITIES OF 4 DERIVATIVES OF ARTEMISIC ACID AND ARTEMISININ-B INVITRO[J]. ACTA PHARMACOLOGICA SINICA,1992,13(6):541-543. |
| APA | SUN, WC,HAN, JX,YANG, WY,DENG, DA,&YUE, XF.(1992).ANTITUMOR ACTIVITIES OF 4 DERIVATIVES OF ARTEMISIC ACID AND ARTEMISININ-B INVITRO.ACTA PHARMACOLOGICA SINICA,13(6),541-543. |
| MLA | SUN, WC,et al."ANTITUMOR ACTIVITIES OF 4 DERIVATIVES OF ARTEMISIC ACID AND ARTEMISININ-B INVITRO".ACTA PHARMACOLOGICA SINICA 13.6(1992):541-543. |
入库方式： OAI收割
来源：上海药物研究所
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