FEEDBACK-REGULATION OF PRESYNAPTIC-D2 RECEPTORS BLOCKADED BY L-STEPHOLIDINE AND L-TETRAHYDROPALMATINE
文献类型：期刊论文
| 作者 | CHEN, LJ; GUO, X; WANG, QM; JIN, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1992-09 |
| 卷号 | 13期号:5页码:442-445 |
| 关键词 | L-STEPHOLIDINE BERBINES L-TETRAHYDROPALMATINE LEVODOPA DOPAMINE RECEPTORS DOPAMINERGIC AGENTS |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | The activity of tyrosine hydroxylase by accumulation of L-dopa content in the striatum under decarboxylase inhibitor (benserazide, 400 mg . kg-1) was measured by HPLC-ECD to ascertain whether l-SPD possesses an agonistic or antagonistic effect on D2 receptor subtype. The accumulated L-dopa content was increased with 1,4-butyrolactone (BL, 750 mg . kg-1) to 1.8 +/- s 0.6-mu-g . g-1 in rat striatum. After the rats were ip l-SPD 5 mg . kg-1 or l-tetrahydropalmatine (l-THP) 10-20 mg . kg-1, the increment of L-dopa level was much more than that in the BL group (P < 0.01) in a dose related manner. On the contrary, apomorphine (ip 5 mg . kg-1) abolished the accumulation of L-dopa induced by BL. Furthermore, l-SPD and l-THP not only reversed the negative feed-back regulation by apomorphine on the accumulated level of L-dopa, but also increased this level over the accumulation by BL. These results showed that l-SPD and l-THP do possess the antagonistic effect on presynaptic DA receptor (D2) without agonistic effect. |
| WOS关键词 | DOPAMINE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:191914 |
| WOS记录号 | WOS:A1992JM88800015 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275149]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | CHEN, LJ |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | CHEN, LJ,GUO, X,WANG, QM,et al. FEEDBACK-REGULATION OF PRESYNAPTIC-D2 RECEPTORS BLOCKADED BY L-STEPHOLIDINE AND L-TETRAHYDROPALMATINE[J]. ACTA PHARMACOLOGICA SINICA,1992,13(5):442-445. |
| APA | CHEN, LJ,GUO, X,WANG, QM,&JIN, GZ.(1992).FEEDBACK-REGULATION OF PRESYNAPTIC-D2 RECEPTORS BLOCKADED BY L-STEPHOLIDINE AND L-TETRAHYDROPALMATINE.ACTA PHARMACOLOGICA SINICA,13(5),442-445. |
| MLA | CHEN, LJ,et al."FEEDBACK-REGULATION OF PRESYNAPTIC-D2 RECEPTORS BLOCKADED BY L-STEPHOLIDINE AND L-TETRAHYDROPALMATINE".ACTA PHARMACOLOGICA SINICA 13.5(1992):442-445. |
入库方式： OAI收割
来源：上海药物研究所
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