EFFECT OF NITROPRUSSIDE (NITRIC-OXIDE) ON ENDOGENOUS DOPAMINE RELEASE FROM RAT STRIATAL SLICES
文献类型：期刊论文
| 作者 | ZHU, XZ; LUO, LG |
| 刊名 | JOURNAL OF NEUROCHEMISTRY
 |
| 出版日期 | 1992-09 |
| 卷号 | 59期号:3页码:932-935 |
| 关键词 | NITRIC OXIDE DOPAMINE RELEASE STRIATUM |
| ISSN号 | 0022-3042 |
| DOI | 10.1111/j.1471-4159.1992.tb08332.x |
| 文献子类 | Article |
| 英文摘要 | It is becoming apparent that the synthesis of nitric oxide (NO) from L-arginine not only explains endothelium-dependent vascular relaxation, but is a widespread mechanism for the regulation of cell function and communication. We examined the role of NO on the endogenous dopamine (DA) release from rat striatum. Nitroprusside, in the concentration range of 3-100-mu-M, induced a dose-dependent increase in the endogenous DA release from rat striatal slices. The maximal response was 330% over the baseline release. A higher concentration of nitroprusside (300-mu-M) produced an inhibitory effect on the spontaneous release of DA. L-Arginine (10 and 100-mu-M), a substrate in the NO-forming enzyme system, also produced an elevation of DA release. L-Arginine-induced DA release was attenuated by N(G)-monomethyl-L-arginine, an inhibitor of NO synthase. NADPH (1-mu-M), a cofactor of NO synthase, enhanced L-arginine-induced DA release. These results suggest a possible involvement of NO in the DA release process in rat striatum. |
| WOS关键词 | NERVOUS-SYSTEM ; L-ARGININE ; BRAIN ; ACTIVATION ; MESSENGER ; CATECHOLAMINES ; GLUTAMATE ; CELLS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:A1992JJ44200016 |
| 出版者 | LIPPINCOTT-RAVEN PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275152]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | ZHU, XZ |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL,319 YUE YANG RD,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | ZHU, XZ,LUO, LG. EFFECT OF NITROPRUSSIDE (NITRIC-OXIDE) ON ENDOGENOUS DOPAMINE RELEASE FROM RAT STRIATAL SLICES[J]. JOURNAL OF NEUROCHEMISTRY,1992,59(3):932-935. |
| APA | ZHU, XZ,&LUO, LG.(1992).EFFECT OF NITROPRUSSIDE (NITRIC-OXIDE) ON ENDOGENOUS DOPAMINE RELEASE FROM RAT STRIATAL SLICES.JOURNAL OF NEUROCHEMISTRY,59(3),932-935. |
| MLA | ZHU, XZ,et al."EFFECT OF NITROPRUSSIDE (NITRIC-OXIDE) ON ENDOGENOUS DOPAMINE RELEASE FROM RAT STRIATAL SLICES".JOURNAL OF NEUROCHEMISTRY 59.3(1992):932-935. |
入库方式： OAI收割
来源：上海药物研究所
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