COMPARISON OF EFFECTS OF TETRAHYDROPALMATINE ENANTIOMERS ON FIRING ACTIVITY OF DOPAMINE NEURONS IN SUBSTANTIA-NIGRA PARS COMPACTA
文献类型：期刊论文
| 作者 | SUN, BC; HUANG, KX; JIN, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1992-07 |
| 卷号 | 13期号:4页码:292-297 |
| 关键词 | TETRAHYDROPALMATINE BERBINES SUBSTANTIA-NIGRA DOPAMINERGIC AGENTS ELECTROPHYSIOLOGY |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Extracellular single unit recording techniques were used to elucidate the effects of enantiomers of tetrahydropalmatine (THP) on the firing activity of dopamine (DA) neurons in substantia nigra pars compacta (SNC). (-)-THP rapidly reversed the apomorphine (Apo)-induced inhibition of the SNC DA cell firing activity (ED50 = 0.77, 0.52-1.14, mg . kg-1), while much larger doses of (+)-THP were required to reverse the Apo-induced inhibition (ED50 = 23, 15.2-34.7, mg . kg-1) and the maximal reversal caused by (+)-THP was 79 +/- 9% of the basal firing rate. In paralyzed rats, (-)-THP (0.5-16 mg . kg-1) significantly increased the spontaneous firing rate of SNC DA neurons dose-dependently, while (+)-THP did not until the dose reached 16 mg . kg-1. Pretreatment with (-)-THP 4 mg . kg-1 attenuated Apo-induced inhibition of SNC DA cell firing rate, while (+)-THP 32 mg . kg-1 revealed a similar potency to block the Apo-induced inhibition. In addition, (+)-THP did not potentiate the effect caused by d-amphetamine (Amp) as some behavioral experiments have shown, but large dose of (+)-THP (32 mg . kg-1) blocked the Amp-induced inhibition of SNC DA cell firing activity as (-)-THP (4 mg . kg-1) did. These results suggest that the interaction between D2 receptors and THP enantiomers has stereoselectivity and that (-)-THP is a D2 antagonist while (+)-THP seems to be not. |
| WOS关键词 | AMPHETAMINE ; BRAIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:191946 |
| WOS记录号 | WOS:A1992JD14000002 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275158]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | SUN, BC |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | SUN, BC,HUANG, KX,JIN, GZ. COMPARISON OF EFFECTS OF TETRAHYDROPALMATINE ENANTIOMERS ON FIRING ACTIVITY OF DOPAMINE NEURONS IN SUBSTANTIA-NIGRA PARS COMPACTA[J]. ACTA PHARMACOLOGICA SINICA,1992,13(4):292-297. |
| APA | SUN, BC,HUANG, KX,&JIN, GZ.(1992).COMPARISON OF EFFECTS OF TETRAHYDROPALMATINE ENANTIOMERS ON FIRING ACTIVITY OF DOPAMINE NEURONS IN SUBSTANTIA-NIGRA PARS COMPACTA.ACTA PHARMACOLOGICA SINICA,13(4),292-297. |
| MLA | SUN, BC,et al."COMPARISON OF EFFECTS OF TETRAHYDROPALMATINE ENANTIOMERS ON FIRING ACTIVITY OF DOPAMINE NEURONS IN SUBSTANTIA-NIGRA PARS COMPACTA".ACTA PHARMACOLOGICA SINICA 13.4(1992):292-297. |
入库方式： OAI收割
来源：上海药物研究所
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